Gastrointestinal manifestations of coronavirus disease 2019

Purpose of review The ubiquitous expression of angiotensin-converting enzyme-2 receptors and its significance as the origin of viral entry have assisted in comprehending the pathophysiology of extrapulmonary manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this review, we focus on the clinical significance of gastrointestinal manifestations. Recent findings The global pandemic, a result of the widespread implications of SARS-CoV-2, remains a significant burden to current healthcare systems. Fever, dyspnea, and tussive symptoms have primarily been recognized as the most common presenting signs/symptoms. During the past one year our scope of practice has transcended beyond the management of the respiratory system to incorporate other varying systemic manifestations such as anorexia, nausea, vomiting, diarrhea, and abdominal pain. The outcomes reported by recent studies suggest an association between the presence of gastrointestinal symptoms and important clinical factors such as delay in presentation, disease severity, and mortality. Summary We provide a summarization of the most recent in-depth investigations of coronavirus disease 2019 with gastrointestinal manifestations and their conclusions. Although the pathophysiology remains an area of evolving interest, a better understanding of this disease process may allow for early recognition, efficient triage, and improved prognostication for those presenting with gast...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: GASTROINTESTINAL INFECTIONS: Edited by James A. Platts-Mills Source Type: research

Related Links:

Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
AbstractPurposeThe trial aimed to investigate the effectiveness of exogenous melatonin as an adjuvant to pregabalin for relief of pain in patients suffering from painful diabetic neuropathy (PDN).Patients and methodsThis randomized, double-blind, placebo-controlled trial was carried out between October 2019 and December 2020 in an outpatient specialty clinic in Iran. One-hundred-three type 2 diabetic patients suffering from PDN were randomized into either the melatonin group (n  = 52) or the placebo group (n = 51). Besides pregabalin at a dose of 150 mg per day, patients started with melato...
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study aimed to understand the extent to which cannabis-related risk perception and COVID-19-related health worries were associated with the reported reduction in sharing cannabis smoking products to mitigate the risk of the coronavirus transmission or infection. This association was tested in two different periods in terms of toughness of national lockdown policy imposed in the first months of the pandemic in Israel. The study population included adult recreational cannabis users who completed one of the two online cross-sectional surveys dedicated to COVID-19 and the cannabis use situation in Israel in the first h...
Source: Drugs and Alcohol Today - Category: Addiction Authors: Source Type: research
“Last March, I was working in a small primary care practice on the west side of Denver. COVID-19 came to town. On Thursday, March 12, we were told the schools would be closing. On Friday, we were told that clinic staff had to wear masks — and the clinic had to start testing patients forRead more …I was thinking about retiring, and COVID-19 gave me a push [PODCAST] originally appeared
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Podcast COVID-19 coronavirus Infectious Disease Primary Care Source Type: blogs
Both Iterion and Moleculin are moving their drug candidates through the regulatory pipeline.
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
The U.S. Food and Drug Administration has given the O.K. to Covid-19 vaccine "booster" shots made by Cambridge biotech Moderna Inc. Moderna (Nasdaq: MRNA) is now able to make and distribute boosters — third shots identical to each of the first two in the series, but half the amount — for patients 65 and older, adults with underlying medical conditions and adults who are at a high risk for Covid-19 because of their occupati ons or time in institutional settings. The decision comes a few days…
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
The foundation has funded $1.9 billion in pandemic-related responses. Its latest pledge is to accelerate access for an experimental antiviral treatment for Covid-19 infections.
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
Khalid J Alzahrani Aristóteles Góes-Neto Vasco Azevedo Preetam Ghosh Debmalya Barh The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-term care of COVID-19 survivors. It is thus imperative to study post-COVID (i.e., short-term) and long-COVID (i.e., long-term) effects, specifically as local and systemic pathophysiological outcomes of other coronavirus-related diseases (such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS)) were well-cataloged. We conducted a comprehensive review of adverse post-COVID health outcomes and ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Manifestaciones extrapulmonares de la infección por SARS-CoV-2. Cir Cir. 2020;88(5):654-663 Authors: Carrillo-Esper R, Melgar-Bieberach RE, Tapia-Salazar M, Jacinto-Flores SA, Campa-Mendoza ÁN, Pérez-Calatayud ÁA, Porres-Aguilar M, Carrillo-Córdova JR, Bracho-Olvera HR, Carrillo-Córdova DM Abstract The disease caused by a new coronavirus, which started in 2019, was named COVID-19 and declared a pandemic on March 11, 2020 by the World Health Organization. Although it is true that the first reports emphasized the respiratory manifestations of this disease as an ...
Source: Cirugia y Cirujanos - Category: Surgery Authors: Tags: Cir Cir Source Type: research
More News: Anorexia | Coronavirus | COVID-19 | Eating Disorders & Weight Management | Gastroenterology | Infectious Diseases | Pain | Pain Management | Pandemics | Respiratory Medicine | SARS | Study