Quality Control of Busulfan Plasma Quantitation, Modeling, and Dosing: An Interlaboratory Proficiency Testing Program

Conclusions: A proficiency testing program by which laboratories are alerted to inaccuracies in their quantitation, pharmacokinetic modeling, and dose recommendations for busulfan in hematopoietic cell transplant recipients was developed. These rounds of proficiency testing suggests that additional educational efforts and proficiency rounds are needed to ensure appropriate busulfan dosing.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Manuscript Source Type: research

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In this study, we use weight independent and microbiome transplant SG models to determine whether increase in natural IgM requires weight loss or the microbiome.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Bariatric and Foregut Source Type: research
Worldwide, healthcare systems were challenged during the COVID-19 pandemic. Tertiary hospitals, which perform the majority of organ transplants in Mexico, shifted gears to provide treatment for critically ill COVID-19 patients.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Global Surgery and Humanitarian Outreach Source Type: research
For patients with severe portal vein thrombosis (PVT), an SMV conduit is usually considered the primary reconstruction option. A left gastric varix (LGV) conduit reconstruction is an alternative which we prefer because it requires less dissection and has less risk of tension and torsion. The aim of this study was to compare the outcomes of patients using an SMV conduit to those using a gastric varix conduit.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
Thromboelastography (TEG) has emerged as a tool to guide resuscitation in Liver Transplantation (LT). We aim to identify effects of TEG utilization on product use and blood loss in LT.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
The obesity epidemic in the United States has led to increasing proportion of obese liver transplant (LT) recipients. Previous studies have not found significant differences in graft survival (GS) and patient survival (PS) between obese and non-obese recipients. However, obesity is a complex, socioeconomic disease that is intrinsically tied with race. Thus, the aim of this work was to analyze the effects of race on liver transplant outcomes in obese recipients.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
We examined actual weight and weight perception among pre-liver transplant patients.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
Cardiac risk stratification is a routine step in the workup of patients awaiting organ transplant. Currently, there is limited data regarding the outcomes of patients undergoing cardiac revascularization to achieve transplant candidacy, particularly in patients receiving percutaneous coronary intervention (PCI). We investigated the outcomes of potential transplant candidates who underwent PCI and assessed their post-intervention outcomes.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
Dramatic increases in drug overdose can have great implications for organ donor pools. History of drug abuse and potential risk of transmittable disease may impact lung transplantation (LTx) donor utilization. We compared the survival outcome of LTx patients utilizing drug overdose vs. non-drug overdose donors and assessed their acute rejection events postoperatively.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
Social factors significantly affect health outcomes, but are often overlooked as causative agents and intervenable targets during program development. While Spanish-speaking patients with end-stage renal disease experience barriers to quality communication and care, there is little research exploring how language affects access to kidney transplantation specifically. We hypothesized that a language barrier, even with the use of translation services, is associated with disproportionate time on the kidney transplant waitlist.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
Live donor transplantation (LD) affords shorter wait time and better outcomes. For legal immigrants or naturalized citizens in the USA, LD candidates may exist in their country of origin but are not considered because of immigration restrictions. We evaluated the impact of targeted petitioning of the US Department of State (DOS) on access to potential foreign national (FN) LD candidates.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
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