Systematic Review and Meta-Analysis of Thiopurine Metabolite Levels and Biochemical Remission in Autoimmune Hepatitis
Conclusions: This meta-analysis suggests a link between 6-TGN levels and biochemical remission in AIH. Further high-quality studies are required to determine the therapeutic cutoff of 6-TGN.
Baby boomers account for three-fourths of all hepatitis C virus (HCV) infections in the United States. At the time of this study, the US Centers for Disease Control and Prevention (CDC) recommended all baby boomers be screened for HCV at least once.
Hepatitis C virus (HCV) infection has been linked to an increased risk of development of diabetes mellitus (DM) which is associated with a higher risk of cardiovascular events. The incidence of new onset DM after transplantation (NODAT) following transplantation of HCV viremic kidneys(D+/R-) into HCV na ïve recipients(D-/R-) is unknown.
Sepsis remains a leading cause of mortality among preterm infants. Hepatitis B (HepB) vaccination has evidence of non-specific effects (NSEs) against heterologous infections. We hypothesized that early HepB vaccination in preterm neonates is associated with advantageous NSEs on infectious complications and mortality during primary admission.
Notice that the Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) is hosting a virtual meeting on November 2-3, 2021. The agenda will include discussions on adult immunization schedule, child/adolescent immunization schedule, Ebola vaccine, hepatitis vaccines, Orthopoxviruses vaccine, and COVID vaccines. Includes information on how to submit public comments or request permission to make a public comment during the meeting. Registration is not required, and the meeting is open to the public, available online via a live webcast.
Pakistan has one of the highest rates of hepatitis C virus (HCV) infection in the world, accounting for over ten per cent of global HCV infections. A new modelling study led by the University of Bristol, UK, suggests that achieving the World Health Organization goal of eliminating HCV as a public health problem by 2030 in Pakistan is likely to be highly cost-effective by 2030, cost-saving by 2031, and could deliver US$9.10 billion in savings to the Pakistan national economy by 2050.
Hepatitis C virus (HCV) is a single-stranded RNA virus of positive polarity [ssRNA(+)] that replicates its genome through the activity of one of its proteins, called NS5B. This viral protein is responsible for copying the positive-polarity RNA genome into a negative-polarity RNA strand, which will be the template for new positive-polarity RNA genomes. The NS5B protein is phosphorylated by cellular kinases, including Akt. In this work, we have identified several amino acids of NS5B that are phosphorylated by Akt, with positions S27, T53, T267, and S282 giving the most robust results. Site-directed mutagenesis of these resid...
Conclusions: Differences in levels of inflammation exist between individuals with HIV/HBV coinfection compared with monoinfected and uninfected controls. A distinct signature of inflammation was associated with HIV/HBV coinfection that could reflect the mechanism of liver fibrosis and increased risk for disease progression. Finally, there may be an underappreciated amount of undiagnosed advanced liver disease in sub-Saharan Africa.
Intern Med. 2021 Oct 19. doi: 10.2169/internalmedicine.8305-21. Online ahead of print.ABSTRACTPrimary hepatocellular carcinoma (HCC) in patients
Emerg Infect Dis. 2021 Nov;27(11):2718-2824. doi: 10.3201/eid2711.204642.ABSTRACTThe United States is currently affected by widespread hepatitis A virus (HAV) outbreaks. We investigated HAV incidence rates among source plasma donors in the United States since 2016. Serial donations from HAV-positive frequent donors were analyzed for common biologic markers to obtain a detailed picture of the course of infection. We found a considerable increase in incidence rates with shifting outbreak hotspots over time. Although individual biomarker profiles were highly variable, HAV RNA typically had a high peak and a biphasic decrease ...
ConclusionWe provide the first clinical evidence that suggests prior HBV infection as an independent favorable prognostic factor for patients with primary cervical cancer.