Risk of rheumatoid arthritis diagnosis in statin users in a large nationwide US study

To evaluate the association between statin use and the risk of developing rheumatoid arthritis (RA) in a large, US case-control study.
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research

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AbstractFilgotinib, an oral Janus kinase-1 preferential inhibitor, is approved in Europe and Japan for adults with rheumatoid arthritis. Patients with rheumatoid arthritis are at higher risk of cardiovascular morbidity/mortality; thus, it is important to understand potential drug-drug interactions of filgotinib with lipid-lowering agents. This open-label, randomized, 2-way crossover study evaluated the pharmacokinetics of atorvastatin, pravastatin, and rosuvastatin with and without filgotinib coadministration. Healthy participants (N = 27) received single doses of atorvastatin (40 mg) and of a pravastatin (40 mg)/rosuvasta...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
Int J Rheumatol. 2021 Aug 12;2021:5535486. doi: 10.1155/2021/5535486. eCollection 2021.ABSTRACTOBJECTIVE: To study the effect of tocilizumab initiation on the lipid profile, in correlation to a composite of any cardiovascular events.METHODS: A retrospective cohort study, using data from the King Faisal Specialist Hospital &Research Centre database, from January 2014 to December 2019. Patients with rheumatoid arthritis or juvenile idiopathic arthritis who were ≥18 years old, initiated either on tocilizumab or other biologic treatment (anti-TNFs or Rituximab), were included, with a follow-up interval duration at a min...
Source: International Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
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