The mechanobiological theory: a unifying hypothesis on the pathogenesis of moyamoya disease based on a systematic review

CONCLUSIONS: Based on the available literature, the authors have proposed a unifying theory for the pathogenesis of MMA. The moyamoya phenomenon appears to be the culmination of an interplay of vascular anatomy, hemodynamics, rheology, blood vessel wall strength, and a plethora of intricately linked mechanobiological molecular mediators that ultimately results in the mechanical process of occlusion of the blood vessel, stimulating angiogenesis and collateral blood supply in an attempt to perfuse the compromised brain.PMID:34469862 | DOI:10.3171/2021.6.FOCUS21281
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Source Type: research