Insights into potential targeted nonsurgical therapies for the treatment of moyamoya disease

Neurosurg Focus. 2021 Sep;51(3):E11. doi: 10.3171/2021.6.FOCUS21289.ABSTRACTSince its initial description in 1957 as an idiopathic disease, moyamoya disease has proved challenging to treat. Although the basic pathophysiology of this disease involves narrowing of the terminal carotid artery with compensatory angiogenesis, the molecular and cellular mechanisms underlying these changes are far more complex. In this article, the authors review the literature on the molecular and cellular pathophysiology of moyamoya disease with an emphasis on potential therapeutic targets.PMID:34469871 | DOI:10.3171/2021.6.FOCUS21289

Source: Neurosurgical Focus - September 1, 2021 Category: Neurosurgery Authors: Dylan Goehner Sandeep Kandregula Christopher P Carroll Mario Zuccarello Bharat Guthikonda Jennifer A Kosty Source Type: research