Differential pre-pandemic breast milk IgA reactivity against SARS-CoV-2 and circulating human coronaviruses in Ugandan and American mothers

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing> 177,100,000 coronavirus disease 2019 (COVID-19) cases by June 18, 2021(World Health Organization, 2021). Uganda, like other African countries, has registered fewer COVID-19 cases and deaths per capita than non-African countries (World Health Organization, 2021). The lower numbers of cases and deaths in Africa by comparison with those in Western countries might be partly due to cross-immunity induced by circulating common cold human corona viruses (HCoVs) (Doshi, 2020).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research

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J Virol Methods. 2021 Oct 8;299:114317. doi: 10.1016/j.jviromet.2021.114317. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has renewed interest in human coronaviruses that cause the common cold, particularly as research with them at biosafety level (BSL)-2 avoids the added costs and biosafety concerns that accompany work with SARS-COV-2, BSL-3 research. One of these, human coronavirus OC43 (HCoV-OC43), is a well-matched surrogate for SARS-CoV-2 because it is also a Betacoronavirus, targets the human respiratory system, is transmitted via respiratory aerosols and dro...
Source: Journal of Virological Methods - Category: Virology Authors: Source Type: research
Int J Environ Res Public Health. 2021 Sep 17;18(18):9785. doi: 10.3390/ijerph18189785.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the novel respiratory disease COVID-19, has reached pandemic status and presents a wide range of manifestations of diverse magnitude, including fever, cough, shortness of breath, and damage to vital organs, such as the heart, lung, kidney, and brain. Normally, older individuals and those with underlying health issues are more at risk. However, about 40% of COVID-19 positive individuals are asymptomatic. This review aims to identify suggested mechanisms of d...
Source: Cell Research - Category: Cytology Authors: Source Type: research
ore Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the novel respiratory disease COVID-19, has reached pandemic status and presents a wide range of manifestations of diverse magnitude, including fever, cough, shortness of breath, and damage to vital organs, such as the heart, lung, kidney, and brain. Normally, older individuals and those with underlying health issues are more at risk. However, about 40% of COVID-19 positive individuals are asymptomatic. This review aims to identify suggested mechanisms of diverse manifestations of COVID-19. Studies suggest that T cell-mediated immunity and s...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
The objective of the study was to assess the prevalence and associated factors of common mental disorders (CMDs) among the informal primary caregivers of adults with mental illness during the Covid-19 epidemic.Methods: A hospital-based cross-sectional study design was conducted from July 1 to 30, 2020. A systematic random sampling technique was used to get samples of informal primary caregivers. Data were analyzed by bivariable and multivariable logistic regression analysis. In the final model, variables having a p-value
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This article summarizes the advanced research progress of LQC in clinical application, mechanisms and provides new clues in the clinical application of LQC.PMID:34385103 | DOI:10.1016/j.biopha.2021.111998
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
Expert Rev Anti Infect Ther. 2021 Jul 6. doi: 10.1080/14787210.2021.1949986. Online ahead of print.ABSTRACTINTRODUCTION: Seven coronavirus species have been identified that can infect humans. While human coronavirus infections had been historically associated with only mild respiratory symptoms similar to the common cold, three coronaviruses identified since 2003, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), cause life-threatening severe respiratory syndromes. The coronavirus disease 2019 (...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Authors: Source Type: research
We present here an overview of the virus interaction with the host and environment and anti-CoV therapeutic strategies; including vaccines and other methodologies, designed for prophylaxis and treatment of SARS-CoV-2 infection with the hope that this integrative analysis could help develop novel therapeutic approaches against COVID-19.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
J Immunol. 2021 Apr 28:ji2001438. doi: 10.4049/jimmunol.2001438. Online ahead of print.ABSTRACTOver the last two decades, there have been three deadly human outbreaks of coronaviruses (CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has caused the current COVID-19 global pandemic. All three deadly CoVs originated from bats and transmitted to humans via various intermediate animal reservoirs. It remains highly possible that other global COVID pandemics will emerge in the coming years caused by yet another spillover of a bat-derived SARS-like coronavirus (SL-CoV) into humans. Determining the Ag and the human B cell...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research
Since the reporting of the first cases of coronavirus in China and the publication of the first sequence of SARS-CoV-2 in December 2019, the virus has undergone numerous mutations. In Europe, the spring outbreak (March –April) was followed by a drop in the number of cases and deaths. The disease may have evolved into a milder form. The increase in PCR-positive cases in late summer 2020 did not lead to the expected increase in hospitalizations, ICU admissions, and deaths, based on the severity of the disease in t he spring. This difference in disease severity could be due to factors independent of the virus or to the ...
Source: Nephron - Category: Urology & Nephrology Source Type: research
Viruses, Vol. 13, Pages 749: From Multiplex Serology to Serolomics—A Novel Approach to the Antibody Response Against the SARS-CoV-2 Proteome Viruses doi: 10.3390/v13050749 Authors: Julia Butt Rajagopal Murugan Theresa Hippchen Sylvia Olberg Monique van Straaten Hedda Wardemann Erec Stebbins Hans-Georg Kräusslich Ralf Bartenschlager Hermann Brenner Vibor Laketa Ben Schöttker Barbara Müller Uta Merle Tim Waterboer The emerging SARS-CoV-2 pandemic entails an urgent need for specific and sensitive high-throughput serological assays to assess SARS-CoV-2 epidemiology. We, ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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