Serum Beta Secretase 1 (BACE1) activity increases in patients with mild cognitive impairment

In conclusion, serum BACE1 activity significantly increased in MCI patients (both amnestic and non-amnestic) compared with Controls. Moreover, higher serum BACE1 activity was observed only among aMCI with a better cognitive performance who progressed to dementia, suggesting that a dysregulation of this enzyme might be an early event primarily associated with neurodegeneration.

Source: Journal of Neurochemistry - September 18, 2021 Category: Neuroscience Authors: Giovanni Zuliani, Alessandro Trentini, Gloria Brombo, Valentina Rosta, Patrizia Guasti, Tommaso Romagnoli, Michele Polastri, Lisa Marabini, Dario Pedrini, Chiara Pistolesi, Salvatore Pacifico, Remo Guerrini, Davide Seripa, Carlo Cervellati Tags: ORIGINAL ARTICLE Source Type: research