Serum Beta Secretase 1 (BACE1) activity increases in patients with mild cognitive impairment

AbstractBeta-secretase1 (BACE1) is considered as the key-enzyme in amyloid- β formation. Previous works suggest that high BACE1 activity may be present in brain, cerebrospinal fluid and serum of patients with late-onset Alzheimer’s disease (LOAD) as well as mild cognitive impairment (MCI).Therefore, we evaluated whether serum BACE1 activity increases in MCI patients and is associated with the progression from MCI to dementia.BACE1 activity was measured in the serum of 259 MCI patients (162 amnestic – aMCI, 97 non-amnestic - naMCI) and 204 healthy Controls. After a median follow-up of 32 months (range: 10-153), 116 MCI progressed to dementia (87 aMCI and 29 naMCI). Serum BACE1 activity was higher in MCI compared with Controls (p
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research

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