Serum Beta Secretase 1 (BACE1) activity increases in patients with mild cognitive impairment

AbstractBeta-secretase1 (BACE1) is considered as the key-enzyme in amyloid- β formation. Previous works suggest that high BACE1 activity may be present in brain, cerebrospinal fluid and serum of patients with late-onset Alzheimer’s disease (LOAD) as well as mild cognitive impairment (MCI).Therefore, we evaluated whether serum BACE1 activity increases in MCI patients and is associated with the progression from MCI to dementia.BACE1 activity was measured in the serum of 259 MCI patients (162 amnestic – aMCI, 97 non-amnestic - naMCI) and 204 healthy Controls. After a median follow-up of 32 months (range: 10-153), 116 MCI progressed to dementia (87 aMCI and 29 naMCI). Serum BACE1 activity was higher in MCI compared with Controls (p
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research

Related Links:

Researchers from Durham University have developed a device that shines light directly into the brain through the skull, which they said could be a 'game-changer' in the fight against dementia.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
HYPERTENSION supplements can help people prevent high blood pressure from progressing into heart attacks, strokes or even dementia. has compiled a list of the best supplements to stave off the potentially dangerous conditions.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conditions:   Alzheimer Disease;   Dementia;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Tauopathies;   Neurocognitive Disorders;   Neurodegenerative Diseases;   Mental Disorders Interventions:   Behavioral: Tele-Savvy;   Behavioral: Caregiving During Crisis (Educational Program) Sponsors:   UConn Health;   Emory University Enrolling by invitation
Source: - Category: Research Source Type: clinical trials
The military population face a unique set of risk factors that may increase the risk of being diagnosed with dementia. Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) have a higher prevalence in this group in comparison to the civili...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
BACKGROUND: Traumatic brain injuries (TBI) among military veterans are increasingly recognized as important causes of both short and long-term neuropsychological dysfunction. However, the association between TBI and the development of dementia is controver...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Frailty has been identified as a risk factor for cognitive impairment and dementia. However, it is not known whether familial factors, such as genetics and shared environmental factors, underlie this associati...
Source: BMC Medicine - Category: Internal Medicine Authors: Tags: Research article Source Type: research
This cross-sectional cohort study evaluates plasma glial fibrillary acidic protein levels throughout the entire Alzheimer disease continuum, from preclinical Alzheimer disease to Alzheimer disease dementia, compared with cerebrospinal fluid glial fibrillary acidic protein.
Source: JAMA Neurology - Category: Neurology Source Type: research
Translational Psychiatry, Published online: 18 October 2021; doi:10.1038/s41398-021-01653-8Prefrontal Aβ pathology influencing the pathway from apathy to cognitive decline in non-dementia elderly
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
We read with great interest the Chu et al article investigating whether patients with dengue have an association with the increasing risk of getting dementia [1]. The result is interesting and provocative. Yet, some points remain to be discussed.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
Why is there such a stigma concerning menopause? It's a natural process that all women who live long enough will go through. Many actually welcome the cessation of their periods, but others dread it as a sign that they are getting "old."   As with most things, the more you know about a topic the better so if you'd like to learn a little more about menopause - or just celebrate the awareness of this month - read more on the Egosancares blog: Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver and am reading it slowly on purpose...I don't want it t...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
More News: Brain | Dementia | Neurology | Neuroscience