Could gene editing chickens prevent future pandemics?

Rearing virus-resistant birds could benefit humans too, say scientists, and Covid may have made us more open to the controversial technologyDiseases such as avian flu trigger the culling of millions of birds each year. But that need not be the case for much longer.Vaccines are one preventive strategy employed in some countries, but they do not stop birds from being infected, getting mild versions of the disease and transmitting it to healthy chickens. In fact, this imperfect shield can make things worse, incentivising the virus to mutate to evade the vaccine.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Gene editing Bird flu Environment Health Society Coronavirus Infectious diseases Medical research Science Chicken Food World news Animals Source Type: news

Related Links:

At least eight types of bird flu, all of which can kill humans, are circulating around the world ’s factory farms – and they could be worse than Covid-19One day last December, 101,000 chickens at a gigantic farm near the city of Astrakhan in southern Russiastarted to collapse and die. Tests by the state research centre showed that a relatively new strain of lethal avian flu known as H5N8 was circulating, and within days 900,000 birds at the Vladimirskaya plant werehurriedly slaughtered to prevent an epidemic.Avian flu is the world ’s other ongoing pandemic and H5N8 is just one strain that has torn through...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Global health Food Bird flu Coronavirus Farming Environment Infectious diseases Medical research Microbiology Science Society World news Wildlife & drink industry Business China Asia Pacific Global development Source Type: news
This article examines strategies to mitigate the transmission of the virus in fitness facilities, including temperature scanning, physical distancing, masks, hand hygiene, and the disinfection of large spaces and common touch surfaces. Fitness facilities and therapy centers face complex challenges in minimizing the risk of viral transmission due to space limitations and the use of common equipment and spaces by clients. Despite these challenges, the developing science resulting from the COVID-19 pandemic has led to insights that should drive policies to help ensure fitness facilities successfully adapt to the risks present...
Source: Strength and Conditioning Journal - Category: Sports Medicine Tags: Article Source Type: research
Trends Genet. 2021 Sep 8:S0168-9525(21)00262-6. doi: 10.1016/j.tig.2021.09.003. Online ahead of print.ABSTRACTSuperspreading and variants of concern (VOC) of the human pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the main catalyzers of the coronavirus disease 2019 (COVID-19) pandemic. However, measuring their individual impact is challenging. By examining the largest database of SARS-CoV-2 genomes The Global Initiative on Sharing Avian Influenza Data [GISAID; n>1.2 million high-quality (HQ) sequences], we present evidence suggesting that superspreading has had a key role in the epidemiologic...
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Source Type: research
The term ‘gain of function’ is perhaps one of the most misunderstood in the scientific lexicon. I would like to explain what the phrase means from the perspective of a scientist who has done gain of function research for the past 40 years. Gain of function (GoF) research gives an organism a new property or […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology avian influenza virus coronavirus COVID-19 ferret gain of function research GOF pandemic viral viruses Source Type: blogs
na‐ômica.BR/MCTI Network Brazil was considered one of the emerging epicenters of the coronavirus pandemic in 2021, experiencing over 3000 daily deaths caused by the virus at the peak of the second wave. In total, the country had more than 20.8 million confirmed cases of COVID-19, including over 582,764 fatalities. A set of emerging variants arose in the country, some of them posing new challenges for COVID-19 control. The goal of this study was to describe mutational events across samples from Brazilian SARS-CoV-2 sequences publicly obtainable on Global Initiative on Sharing Avian Influenza Data-EpiCoV (GISAID-...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
We present here a comprehensive analysis of the composition and codon usage bias of the 82 Orthocoronavirinae members, infecting 47 different avian and mammalian hosts. Our results clearly establish that synonymous codon usage varies widely among viruses, is only weakly dependent on their primary host, and is dominated by mutational bias towards AU-enrichment and by CpG avoidance. Indeed, variation in GC3 explains around 34%, while variation in CpG frequency explains around 14% of total variation in codon usage bias. Further insight on the mutational equilibrium within Orthocoronavirinae revealed that most coronavirus geno...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Environ Res. 2021 Aug 19:111909. doi: 10.1016/j.envres.2021.111909. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 genomes have been sequenced massively and worldwide and are now available in different public genome repositories. There is much interest in generating bioinformatic tools capable to analyze and interpret SARS-CoV-2 variation. We have designed CovidPhy (http://covidphy.eu), a web interface that can process SARS-CoV-2 genome sequences in plain fasta text format or provided...
Source: Environmental Research - Category: Environmental Health Authors: Source Type: research
In conclusion, the levels of cytokines in COVID-19 were significantly correlated with the severity of the disease in the early stage, and serum cytokines could be used as warning indicators of the severity and progression of COVID-19. Early stratification of disease and intervention to reduce hypercytokinaemia may improve the prognosis of COVID-19 patients.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - Category: Microbiology Authors: Source Type: research
(Natural News) Fear is perhaps the most effective, reliable and proven weapon for tyrants to control people. The same is true in medical tyranny. Members of the Scientific Pandemic Influenza Group on Behavior (SPI-B) expressed regret about the “unethical” and “totalitarian” tactics in a new book about the role of psychology in the UK government’s...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
More News: Bird Flu | Bird Flu (H5N1 Avian Influenza) Vaccine | Coronavirus | COVID-19 | Environmental Health | Genetics | Infectious Diseases | Pandemics | Research | Science | Vaccines | Veterinary Vaccinations