Barrett ’s Epithelium to Esophageal Adenocarcinoma: Is There a “Point of No Return”?

Discussion: The transcriptomic gene expression patterns in the BEC model demonstrate evidence of a clear threshold in the progression of BE to malignancy. Catastrophic transcriptomic changes during a window period culminate in the commitment of the BE cells to a “point of no return,” and removal of ABS is not effective in preventing their malignant transformation. Discerning this “point of no return” during BE surveillance by tracking the GEPs has the potential to evaluate risk of BE progression and enable personalized clinical management.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research