Liver surface nodularity on non-contrast MRI identifies advanced fibrosis in patients with NAFLD

AbstractObjectivesTo evaluate the diagnostic performance of liver surface nodularity (LSN) for the assessment of advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).MethodsWe retrospectively analysed patients with pathologically proven NAFLD who underwent liver MRI. Demographic, clinical, and laboratory data (including FIB-4 scores) were gathered. The SAF score was used to assess NAFLD. MRI-proton density fat fraction (PDFF) and LSN were determined on pre-contrast MR sequences. ROC curve analysis was performed to evaluate the diagnostic performance of MRI-LSN for the diagnosis of advanced (F3-F4) liver fibrosis.ResultsThe final population included 142 patients. Sixty-seven (47%) patients had non-alcoholic steatohepatitis (NASH), and 52 (37%) had advanced fibrosis. The median MRI-PDFF increased with the grades of steatosis: 8.1%, 18.1%, and 31% in S1, S2, and S3 patients, respectively (p 
Source: European Radiology - Category: Radiology Source Type: research

Related Links:

In conclusion, SFN ameliorates lipid metabolism disorders in NAFLD mice by upregulating FGF21/FGFR1 pathway. Our results verify that SFN may become a promising intervention to treat or relieve NAFLD.PMID:34654875 | DOI:10.1038/s41401-021-00786-2
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSION: Our data clearly demonstrate that chronic fructose supplementation, as the sole dietary intervention, does not cause HCC development in rats.PMID:34650394 | PMC:PMC8494264 | DOI:10.29219/fnr.v65.7670
Source: Food and Nutrition Research - Category: Nutrition Authors: Source Type: research
Biomed Pharmacother. 2021 Nov;143:112181. doi: 10.1016/j.biopha.2021.112181. Epub 2021 Oct 4.ABSTRACTJiangzhi Granule is a commonly used traditional Chinese medicine for treating non-alcoholic fatty liver disease. However, its key ingredients and underlying mechanisms for attenuating nonalcoholic steatohepatitis (NASH) remain unclear. To address this issue, UPLC-TOF-MS based chemical profiling, network pharmacology and animal experimental validation were employed. First, a total of 56 main ingredients of Jiangzhi Granule and 38 ingredients in the blood and liver (after oral administration) were identified. Then, 170 potent...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSION: In Mexico, non-alcoholic fatty liver disease affect people with obesity, diabetes, and metabolic syndrome as well as men, subjects of low socioeconomic status, subjects who live in rural areas and indigenous population. Interventions to reduce this condition should be a public health priority.PMID:34653686 | DOI:10.1016/j.aohep.2021.100562
Source: Annals of Hepatology - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: Our data clearly demonstrate that chronic fructose supplementation, as the sole dietary intervention, does not cause HCC development in rats.PMID:34650394 | PMC:PMC8494264 | DOI:10.29219/fnr.v65.7670
Source: Food and Nutrition Research - Category: Nutrition Authors: Source Type: research
Mol Cell Biochem. 2021 Oct 15. doi: 10.1007/s11010-021-04269-0. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) was a world-wide health burden. H3K27 acetylation, long non-coding RNA (lncRNA), and miRNA were all implicated in NAFLD regulation, yet the detailed regulatory mechanism was not well understood. LncRNA NEAT1, miR-212-5p, and GRIA3 expression were detected both in high fatty acid-treated hepatocytes cells and NAFLD patients. Lipid droplets were stained and analyzed by oil red O staining. Expression of fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), and GRIA3 was detected by qRT-PC...
Source: Molecular and Cellular Biochemistry - Category: Biochemistry Authors: Source Type: research
CONCLUSION: Our data clearly demonstrate that chronic fructose supplementation, as the sole dietary intervention, does not cause HCC development in rats.PMID:34650394 | PMC:PMC8494264 | DOI:10.29219/fnr.v65.7670
Source: Food and Nutrition Research - Category: Nutrition Authors: Source Type: research
CONCLUSION: In Mexico, non-alcoholic fatty liver disease affect people with obesity, diabetes, and metabolic syndrome as well as men, subjects of low socioeconomic status, subjects who live in rural areas and indigenous population. Interventions to reduce this condition should be a public health priority.PMID:34653686 | DOI:10.1016/j.aohep.2021.100562
Source: Annals of Hepatology - Category: Gastroenterology Authors: Source Type: research
J Sports Med Phys Fitness. 2021 Oct;61(10):1416-1422. doi: 10.23736/S0022-4707.20.11693-1.ABSTRACTBACKGROUND: Oxidative stress and mitochondrial dysfunction can be tracked down in most liver diseases like non-alcoholic fatty liver disease (NAFLD). The most recommended preventative method is lifestyle modification, especially exercise. The aim of this study was the investigation of changes in the indexes of mitochondrial biogenesis and fatty liver indicators in rat following continuous and high intensity interval training.METHODS: Thirty healthy male rats were divided into three control (C=10), Continuous swimming training ...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Authors: Source Type: research
This study aimed to determine the risk factors for newly developed NAFLD among breast cancer patients after hormonal treatment and whether it influences survival outcomes.METHODS: This retrospective study investigated hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative (HR+/HER2-), nonmetastatic breast cancer patients diagnosed between January 2010 and December 2018. All patients received adjuvant hormonal treatment for at least 6 months. Clinical data on metabolic profile indicators such as body mass index (BMI), waist circumference, serum cholesterol, triglycerides, low-density lipopr...
Source: Journal of Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
More News: Alcoholism | Fatty Liver Disease (FLD) | Laboratory Medicine | Liver | Liver Disease | Non-alcoholic Fatty Liver Diseases (NAFLD) | Radiology | Urology & Nephrology