Viruses, Vol. 13, Pages 1856: Advancing Our Understanding of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms and Future Therapeutics
Viruses, Vol. 13, Pages 1856: Advancing Our Understanding of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms and Future Therapeutics
Viruses doi: 10.3390/v13091856
Authors:
Emily Greenan
Sophie Gallagher
Rana Khalil
Conor C. Murphy
Joan Ní Gabhann-Dromgoole
Herpes stromal keratitis (HSK) is a disease that commonly affects the cornea and external eye and is caused by Herpes Simplex Virus type 1 (HSV-1). This virus infects approximately 66% of people worldwide; however, only a small portion of these people will develop symptoms in their lifetime. There is no cure or vaccine available for HSV-1; however, there are treatments available that aim to control the inflammation caused by the virus and prevent its recurrence. While these treatments are beneficial to those suffering with HSK, there is a need for more effective treatments to minimise the need for topical steroids, which can have harmful effects, and to prevent bouts of disease reactivation, which can lead to progressive corneal scarring and visual impairment. This review details the current understanding of HSV-1 infection and discusses potential novel treatment options including microRNAs, TLRs, mAbs, and aptamers.
Source: Viruses - Category: Virology Authors: Emily Greenan Sophie Gallagher Rana Khalil Conor C. Murphy Joan N í Gabhann-Dromgoole Tags: Review Source Type: research