nLower incidence of Cytomegalovirus reactivation following post-transplant cyclophosphamide HLA mismatched unrelated donor transplantation

The use of haploidentical or HLA mismatched unrelated donors (MMUD) allows allogeneic hematopoietic cell transplantation (HCT) in individuals without suitable matched donors. Post-transplant cyclophosphamide (PTCy) is used routinely for prevention of graft-versus-host disease (GVHD) in recipients of haploidentical transplants and its use has been recently explored in MMUD transplantation.

Source: Biology of Blood and Marrow Transplantation - September 16, 2021 Category: Hematology Authors: Jose F Camargo, Yosuke Ebisu, Antonio Jimenez-Jimenez, Yoichiro Natori, Ilona Moroz, Michele I Morris, Maritza Alencar, Anthony D Anderson, Lazaros Lekakis, Amer Beitinjaneh, Mark Goodman, Trent Wang, Denise Pereira, Krishna V. Komanduri Source Type: research