Melatonin Maintains Anabolic-Catabolic Equilibrium and Regulates Circadian Rhythm During Osteoarthritis Development in Animal Models: A Systematic Review and Meta-analysis

Background: The driving force behind osteoarthritis (OA) pathogenesis is an anabolic-catabolic (a/c) imbalance. Melatonin (MT) is a key player in maintaining a/c stability and mitigates OA pathogenesis, but mechanisms underlying its effects remain poorly understood.Objectives: We performed a systematic review analyzing the experimental data that support the clinical applicability of MT in the treatment of OA pathogenesis, placing particular emphasis on the regulation of circadian rhythms and a/c balance.Methods: Major electronic databases and grey literature were used to identify related original articles. Methodological quality of all selected studies was evaluated using the SYRCLE risk of bias tool. Pooled mean differences (MDs)/standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated to estimate the effect size.Results: Eleven trials were included in this systematic review. Compared with the control group, MT significantly decreased the levels of interleukin-1β (IL-1β; SMD = −5.45; 95% CI [−6.78, −4.12]; p
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Steve Backshall was diagnosed with Osteoarthritis which affects around a third of people in the UK aged 45 and over. It happened after his stint on Strictly Come Dancing.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conditions:   Osteoarthritis;   Osteo Arthritis Knee Interventions:   Drug: LY356318;   Drug: Placebo Sponsor:   Eli Lilly and Company Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Piezo2 mechanotransduction channel is a crucial mediator of sensory neurons for sensing and transducing touch, vibration, and proprioception. We here characterized Piezo2 expression and cell specificity in rat peripheral sensory pathway using a validated Piezo2 antibody. Immunohistochemistry using this antibody revealed Piezo2 expression in pan primary sensory neurons of dorsal root ganglia in naïve rats, which was actively transported along afferent axons to both central presynaptic terminals innervating the spinal dorsal horn (DH) and peripheral afferent terminals in the skin. Piezo2 immunoreactivity (IR) was also d...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
The objective is to study the effect of this program on disease activity in patients with RA (randomized controlled trial [RCT] 1), on a risk score for developing RA in patients with anti-citrullinated protein antibody (ACPA) positive arthralgia (RCT 2) and on pain, stiffness, and function in patients with MSOA (RCT 3), all in comparison with usual care.We designed three 16-week observer-blind RCTs with a waiting-list control group for patients with RA with low to moderate disease activity (2.6 ≤ Disease Activity Score [DAS28] ≤ 5.1, RCT 1,n = 80), for patients at risk for RA, defined by ACPA-positive arthralgia (RCT...
Source: Trials - Category: Research Source Type: clinical trials
CONCLUSION: There was a novel circ_0045714/miR-331-3p/PIK3R3 ceRNA axis in HAC, and its inhibition might be one mechanism of HAC injury in OA.PMID:34649564 | DOI:10.1186/s13018-021-02738-2
Source: Cell Research - Category: Cytology Authors: Source Type: research
In conclusion, FABP4 knockdown suppressed the inflammation, oxidative stress, apoptosis and extracellular matrix degradation of IL‑1β‑induced chondrocytes by activating PPARγ to inhibit the NF‑κB signaling pathway.PMID:34651666 | DOI:10.3892/mmr.2021.12495
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
CONCLUSIONS: A postoperative regimen with early mobilization after trapeziectomy is as safe and effective as a postoperative regimen with longer immobilization in patients with first carpometacarpal osteoarthritis.TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic II.PMID:34649742 | DOI:10.1016/j.jhsa.2021.08.015
Source: Hand Surgery - Category: Surgery Authors: Source Type: research
In conclusion, FABP4 knockdown suppressed the inflammation, oxidative stress, apoptosis and extracellular matrix degradation of IL‑1β‑induced chondrocytes by activating PPARγ to inhibit the NF‑κB signaling pathway.PMID:34651666 | DOI:10.3892/mmr.2021.12495
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
CONCLUSIONS: A postoperative regimen with early mobilization after trapeziectomy is as safe and effective as a postoperative regimen with longer immobilization in patients with first carpometacarpal osteoarthritis.TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic II.PMID:34649742 | DOI:10.1016/j.jhsa.2021.08.015
Source: Hand Surgery - Category: Surgery Authors: Source Type: research
ConclusionsExisting low-quality studies show Subchondroplasty ® to benefit patients with BMLs through reduction in pain and improvement in function, along with a high degree of satisfaction following the procedure. The low short-to-medium term conversion rate to arthroplasty suggests that Subchondroplasty® may play a role in delaying more invasive and expens ive procedures in patients with BMLs. Subchondroplasty® is a novel procedure that has promising initial findings, but requires further high-quality, comparative studies with long-term follow-up to better understand the outcomes of the procedure and impact c...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
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