To Be or Not To Be Vaccinated: That Is a Question in Myasthenia Gravis

Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and abnormal fatigability due to the antibodies against postsynaptic receptors. Despite the individual discrepancy, patients with MG share common muscle weakness, autoimmune dysfunction, and immunosuppressive treatment, which predispose them to infections that can trigger or exacerbate MG. Vaccination, as a mainstay of prophylaxis, is a major management strategy. However, the past years have seen growth in vaccine hesitancy, owing to safety and efficacy concerns. Ironically, vaccines, serving as an essential and effective means of defense, may induce similar immune cross-reactivity to what they are meant to prevent. Herein, we outline the progress in vaccination, review the current status, and postulate the clinical association among MG, vaccination, and immunosuppression. We also address safety and efficacy concerns of vaccination in MG, in relation to COVID-19. Since only a handful of studies have reported vaccination in individuals with MG, we further review the current clinical studies and guidelines in rheumatic diseases. Overall, our reviews offer a reference to guide future vaccine clinical decision-making and improve the management of MG patients.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Conclusion: Our systematic review indicated the potential of the COVID-19 virus to trigger a myriad of autoimmune and rheumatic manifestations, which should be considered amid global efforts to combat COVID-19.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
As effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge, it is important to have timely real-word data that guides immunization prioritization for our patients and especially possibly more vulnerable neuromuscular populations [1]. Recent data have shown that patients with chronic autoimmune neuromuscular disorders who are on immunosuppression were more likely to require hospitalization with Coronavirus Disease 2019 (COVID-19) [2]. Similarly, recent preliminary data published from the COVID-19 Associated Risks and Effects in Myasthenia Gravis (CARE-MG) registry, demonstrated a morta...
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ConclusionsLack of availability of sound scientific knowledge inevitably lead unreliable news to spread over the population, preventing people to disentangle them form reliable information. Even if additional studies are needed to replicate and strengthen our results, these findings represent initial evidence to derive recommendations based on actual data for subjects with autoimmune diseases.
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