Comparison of Treatment Regimens for Helicobacter pylori Infection

Am Fam Physician. 2021 Sep 1;104(3):Online.NO ABSTRACTPMID:34523899
Source: American Family Physician - Category: Primary Care Authors: Source Type: research

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During autophagy defense against invading microbes, certain lipid types are indispensable for generating specialized membrane-bound organelles. The lipid composition of autophagosomes remains obscure, as does ...
Source: Journal of Biomedical Science - Category: Biomedical Science Authors: Tags: Research Source Type: research
Early detection and appropriate treatment of precancerous, mucosal changes could significantly decrease the prevalence of life-threatening gastric cancer. Biopsy of the normal-appearing mucosa to detect Helicobac...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
A new clinical practice update of atrophic gastritis focuses on cases linked to Helicobacter pylori infection or autoimmunity.Medscape Medical News
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Gastroenterology News Source Type: news
In this study, we aimed to investigate the prevalence of bab genes (babA, babB, babC) at their three loci (loci A, B, and C) in Helicobacter pylori strains from varied clinical manifestations of Korean gastroduodenal patients. The overall prevalence of H. pylori Korean strains positive for babA and babB was 91.1% and 92.2%, respectively, but all strains were negative for babC. H. pylori strains with two loci occupied (loci A and B) were the most prevalent in Korean patients (85.6%), compared to one locus occupied (14.4%) (locus A or B). Twelve bab genotypes were detected, additionally, the distribution of three bab genotyp...
Source: New Microbiologica - Category: Microbiology Authors: Source Type: research
Traditional medicines embody knowledge on medicinal plants that has been accumulated through cultural evolution over millennia. In the latter half of the 20th century, two approaches to medicinal plant research have been established: the “Bench to Bedside” and the “Bedside to Bench” approaches which serve primarily for the development of more efficient therapeutics. Here, we propose a third, novel approach: from “Tradition to Pathogenesis” which aims to understand the pathogenesis of diseases based on the cultural evolution of their respective empirical treatments. We analyse multiple ex...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, when screening techniques were compared to no-screening, serology screening techniques showed to be cost-effective. The lowest ICER calculated was US$$1230 cost per life-year gained (LYG) and US$1500 cost per quality-adjusted life-year (QALY). However, determining the optimal strategy compared to other strategies was depended on parameters such as context-specific, type of cost, threshold, and perspective, and also, it influenced by the framework of the cost-effectiveness analysis.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
J Clin Med. 2021 Oct 18;10(20):4772. doi: 10.3390/jcm10204772.ABSTRACTUp-to-date studies emphasize the role of human urinary and intestinal microbiome in maintaining urogenital health. Both microbial flora and sexually transmitted pathogens may affect metabolic or immune mechanisms and consequently promote or inhibit prostate carcinogenesis. Hereby, we review the most current evidence regarding the microbial factors and their link to prostate cancer. We conducted a literature search up to December 2020. The microbial impact on prostate cancer initiation and progression is complex. The proposed mechanisms of action include ...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: Obesity leads to a baseline state of chronic inflammation and increased production of pro-inflammatory cytokines that can stimulate the lymphocytes, leading to lymphomatous proliferation. Our study suggests a potential correlation between obesity and the risk of development of primary gastric MALT lymphoma.PMID:34686502
Source: Annals of Clinical and Laboratory Science - Category: Laboratory Medicine Authors: Source Type: research
ChemMedChem. 2021 Oct 23. doi: 10.1002/cmdc.202100618. Online ahead of print.ABSTRACTThirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2'-dithiobis(N-(2-fluorophenyl)acetamide) (d7), 2,2'-dithiobis(N-(3,5-difluorophenyl)acetamide) (d24), and 2,2'-dithiobis(N-(3-fluorophenyl)acetamide) (d8) were her...
Source: ChemMedChem - Category: Chemistry Authors: Source Type: research
CONCLUSION: ITIH4 is a key biomarker in serum from patients with EGC and has potential as a high value diagnostic marker for EGC.PMID:34687700 | DOI:10.1016/j.cca.2021.10.022
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Source Type: research
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