Study finds ADHD is associated with dementia

We examined the extent to which attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental disorder, is linked with Alzheimer’s disease (AD) and any dementia, neurodegenerative diseases, across generations… Results: Among relatives of 2,132,929 index persons, 3042 parents, 171,732 grandparents, and 1369 uncles/aunts had a diagnosis of AD. Parents of individuals with ADHD had an increased risk of AD (hazard ratio 1.55, 95% confidence interval 1.26–1.89). The associations attenuated but remained elevated in grandparents and uncles/aunts. The association for early-onset AD was stronger than late-onset AD. Similar results were observed for any dementia. Discussion: ADHD is associated with AD and any dementia across generations. The associations attenuated with decreasing genetic relatedness, suggesting shared familial risk between ADHD and AD. The Study in Context: What are cognitive abilities and how to boost them? Study shows why children with ADHD should be reevaluated each year: Attention problems perceived by teachers are far less stable than we imagine Study: High Cognitive Reserve (CR) seen to significantly lower dementia risk even in the presence of high Alzheimer’s Disease (AD) neuropathology The post Study finds ADHD is associated with dementia appeared first on SharpBrains.
Source: SharpBrains - Category: Neuroscience Authors: Tags: Attention & ADD/ADHD Brain/ Mental Health Alzheimers-disease attention-deficit/hyperactivity disorder cognitive cognitive decline cognitive-abilities dementia neurodegenerative-diseases Neurodevelopmental Source Type: blogs

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World Psychiatry. 2021 Oct;20(3):417-436. doi: 10.1002/wps.20894.ABSTRACTDecades of research have revealed numerous risk factors for mental disorders beyond genetics, but their consistency and magnitude remain uncer-tain. We conducted a "meta-umbrella" systematic synthesis of umbrella reviews, which are systematic reviews of meta-analyses of individual studies, by searching international databases from inception to January 1, 2021. We included umbrella reviews on non-purely genetic risk or protective factors for any ICD/DSM mental disorders, applying an established classification of the credibility of the evidenc...
Source: World Psychiatry - Category: Psychiatry Authors: Source Type: research
We examined the extent to which attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental disorder, is linked with Alzheimer's disease (AD) and any dementia, neurodegenerative diseases, across generations.METHODS: A nationwide cohort born between 1980 and 2001 (index persons) were linked to their biological relatives (parents, grandparents, uncles/aunts) using Swedish national registers. We used Cox models to examine the cross-generation associations.RESULTS: Among relatives of 2,132,929 index persons, 3042 parents, 171,732 grandparents, and 1369 uncles/aunts had a diagnosis of AD. Parents of individuals with A...
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research
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