A genomic snapshot of < i > Salmonella enterica < /i > serovar Typhi in Colombia
by Paula Diaz Guevara, Mailis Maes, Duy Pham Thanh, Carolina Duarte, Edna Catering Rodriguez, Lucy Angeline Monta ño, Thanh Ho Ngoc Dan, To Nguyen Thi Nguyen, Megan E. Carey, Josefina Campos, Isabel Chinen, Enrique Perez, Stephen Baker
Little is known about the genetic diversity ofSalmonella enterica serovar Typhi (S. Typhi) circulating in Latin America. It has been observed that typhoid fever is still endemic in this part of the world; however, a lack of standardized blood culture surveillance across Latin American makes estimating the true disease burden problematic. The Colombian National Health Service established a surveillance system for tracking bacterial pathogens, includingS. Typhi, in 2006. Here, we characterized 77 representative ColombianS. Typhi isolates collected between 1997 and 2018 using pulse field gel electrophoresis (PFGE; the accepted genotyping method in Latin America) and whole genome sequencing (WGS). We found that the mainS. Typhi clades circulating in Colombia were clades 2.5 and 3.5. Notably, the sequencedS. Typhi isolates from Colombia were closely related in a global phylogeny. Consequently, these data suggest that these are endemic clades circulating in Colombia. We found that AMR inS. Typhi in Colombia was uncommon, with a small subset of organisms exhibiting mutations associated with reduced susceptibility to fluoroquinolones. This is the first time thatS. Typhi isolated from Colombia have been characterized by WGS, and after comparing these ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Paula Diaz Guevara Source Type: research
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