Acute neutrophilic gastritis induced by nivolumab used as a treatment of non- metastatic malignant melanoma
We present a 47 year-old man with a personal history of malignant melanoma (pT3bN2M0) radically removed, who was receiving adjuvant Nivolumab for prevention of recurrence. He was admitted to our service complaining of epigastric pain and hyporexia after receiving the 9º dose of Nivolumab. He underwent a preferential esophagogastroduodenoscopy which showed an intense inflammation limited to the stomach. Macroscopically all the mucosa was erythematosus, edematous, with friability and large ulcerations covered with fibrin. Multiple biopsies revealed inflammatory neutrophilic infiltration in the epithelium, cellular apoptosis and crypt microabscesses, all of which was related to Nivolumab drug-induced pangastritis. No form of Helicobacter Pylori was identified. A medical treatment with double dose of proton-pump inhibitor and definitive cessation of Nivolumab was established, becoming the patient rapidly asymptomatic. The immune checkpoint inhibitors are becoming a widespread treatment in the Oncology field. Nivolumab is a PD-L1 inhibitor, leading to the activation of the cytotoxic immune response carried out by LT-CD8 (1). Despite the immune-mediated adverse events related to the lower gastrointestinal tract are well known; the gastritis or the esophagitis remain sporadic effects (2). They can appear several months after the beginning of the treatment but also after its discontinuation. The differential diagnosis must be reached by excluding pathologies such as infectious g...
Meeting of the Working Group on the National Mental Health Strategic Plan, April 2019By Saima Wazed and Nazish ArmanDHAKA, Oct 27 2021 (IPS) Mental health is a state of well-being when both your body and your mind are in balance, and you are able to deal with the difficulties and challenges that come your way and easily find joy, peace, and happiness once the challenge is overcome. For many people though, the challenges often remain for too long – the pain of losing someone you dearly loved, being diagnosed with a chronic disease like cancer or a heart condition, losing your family/home/job or feeling like you failed...
When treating pain in multiple sclerosis, a specialist is urging colleagues to think outside the box - especially since pain can evolve over time due to changes in MS and related conditions.Medscape Medical News
Dosing and cost uncertainties keep customized liquid drops from reaching mainstream
Conditions: COVID-19; Vaccine Adverse Reaction; Vaccine Reaction; Vaccine or Biological Substance, Unspecified Causing Adverse Effects in Therapeutic Use; Corona Virus Infection; Blood Clot; Thrombocytopenia; Neuritis; Vasculitis; Influenza Intervention: Biological: vaccinated Sponsors: Neuroganics LLC; Ramos Injury Law Firm Not yet recruiting
Condition: Ankylosing Spondylitis Intervention: Other: questionnaires and inventories Sponsor: Bozyaka Training and Research Hospital Recruiting
Conditions: Advanced Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stag e IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8 Interventions: Dietary Suppl...
Condition: Moderate to Severe Acute Lower Back Pain Interventions: Drug: SP-103; Drug: Placebo Sponsors: Scilex Pharmaceuticals, Inc.; Worldwide Clinical Trials Not yet recruiting
Conditions: Esketamine; Pregabalin; Perioperative Complication; Neuropathic Pain; Neurosurgical Procedures; Acute Postoperative Pain; Spinal Cord Neoplasms Interventions: Drug: S-ketamine and pregabalin; Drug: Normal saline and placebo capsule Sponsor: Beijing Tiantan Hospital Not yet recruiting