Acquired Hemophilia A

Acquired hemophilia A is a potentially severe bleeding disorder caused by antibodies against the patient ’s own factor VIII. Acquired hemophilia A is rare. It is most commonly diagnosed in older individuals; about one-half of cases of acquired hemophilia are associated with underlying conditions, including autoimmune disease, cancer, and pregnancy. The diagnosis of acquired hemophilia A can be suspec t with an isolated activated partial thromboplastin time elevation, and confirmed with demonstration of reduced factor VIII activity and the presence of a specific factor VIII inhibitor. Treatment of acquired hemophilia A involves control of bleeding, and eradication of the inhibitor.
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Source Type: research