Increased Risk for Ipsilateral Breast Tumor Recurrence in Invasive Lobular Carcinoma after Accelerated Partial Breast Irradiation Brachytherapy

CONCLUSIONS: These results show that APBI is an effective treatment for patients with invasive breast cancer. Expansion of the current eligibility criteria should be considered, though prospective validation is needed. Caution is required when considering APBI for patients with ILC.IMPLICATIONS FOR PRACTICE: In a large retrospective review of 946 patients with early breast cancer treated with partial mastectomy and APBI intracavitary brachytherapy, we demonstrate durable local control. Patients deemed unsuitable or high risk by the American Brachytherapy Society, American Society of Therapeutic Radiation Oncology, and European Society for Radiotherapy and Oncology guidelines were not at increased risk for IBTR, suggesting that expansion of the current criteria should be considered. Importantly, however, our results demonstrate that caution should be taken when considering APBI for patients with invasive lobular carcinoma, as these patients had relatively high risk for IBTR (10-year IBTR 14%).PMID:34516030 | DOI:10.1002/onco.13980
Source: The Oncologist - Category: Cancer & Oncology Authors: Source Type: research

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ConclusionThe ability of mammography and breast ultrasound to accurately measure residual tumor size following neoadjuvant chemotherapy compared to Breast MRI measurement of the residual tumor demonstrated sensitivity of 94.12 % and specificity of 83.33% with high accuracy value reaching to 91.30 %. Even that the MRI is proved to be of high accuracy in detecting residual tumor, sonomammographic imaging isa cost-effective imaging modality than the MRI with sensitivity and specificity near to that of MRI.
Source: QJM - Category: Internal Medicine Source Type: research
CONCLUSION: Non-surgical management of pure LN is safe, and the likelihood of requiring subsequent surgical excision or repeat CNB during follow-up is low. These data provide reassurance that routine excision of pure LN in the setting of radiologic-pathologic concordance is not required.PMID:34554341 | DOI:10.1245/s10434-021-10827-z
Source: Ann Oncol - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: BI-RADS findings correspond to similar studies, however, a large number of benign breast disease was diagnosed. This may indicate heightened clinical awareness of breast cancer diagnosis and early detection. A significant percentage of malignancies presented as locally advanced. Except for a lower number of invasive lobular carcinoma, the histological spectrum of malignant disease is similar to comparative studies.PMID:34515426
Source: South African Journal of Surgery - Category: Surgery Authors: Source Type: research
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