Prognostic Relevance of Pancreatic Adenocarcinoma Whole-tumor Transcriptomic Subtypes and Components

In this study, we compared the robustness of quantitative components and qualitative classifications from different transcriptomic profiling techniques, investigated their clinical relevance and proposed a new prognostic model.EXPERIMENTAL DESIGN: 210 patients from a multicentric cohort and 149 patients from a monocentric cohort were included in this study. RNA micro-arrays profiles were obtained from 165 patients of the multicentric cohort. RNA sequencing (RNA-seq) profiles were obtained from all the patients.RESULTS: For the patients with both RNA micro-array and RNA-seq profiles, the concordance in subtype assignment was partial with an 82.4% coherence rate. The correlation between the two techniques projections of the six components ranged from 0.85 to 0.95, demonstrating an advantage of robustness. Based on the Akaike Information criterion, the RNA components showed more prognostic value in univariate or multivariate models than the subtypes. Using the monocentric cohort for training, we developed a multivariate Cox regression model using all six components and clinicopathological characteristics (node invasion and resection margins) on DFS. This prognostic model was highly associated with DFS (p
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Source Type: research

Related Links:

Cancer Biol Ther. 2021 Oct 25:1-5. doi: 10.1080/15384047.2021.1991739. Online ahead of print.ABSTRACTMetastatic pancreatic adenocarcinoma (PDAC) is a rapidly lethal disease, with less than half of patients surviving 12 months, and 5-year survival approximately 3%. These outcomes are in large part due to a lack of effective medical and surgical therapies for metastatic PDAC. Herein, we present the case of a patient with oligometastatic liver recurrence of BRCA2-mutated PDAC following a curative-intent resection. Through a combination of systemic chemotherapy, metastasectomy, radiotherapy, and subsequent targeted therapy wit...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: Modulating B cell development, neoangiogenesis and fibrosis, and SDF-1/CXCL12 may play a role in IgG4-RD. The higher levels observed in IgG4-RD, as compared to SSj, which closely mimics the disease, can be related to a different pattern of lesions, with prevalent fibrosis seen in IgG4-RD. Taken together, these findings suggest that drugs acting on the CXCL12/CXCR4/CXCR7 axis may affect IgG4-RD.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Experimental &Molecular Medicine, Published online: 26 October 2021; doi:10.1038/s12276-021-00687-8Boosting the activity of a tumor suppressor pathway in pancreatic cancer may reduce the risk of metastasis. Reduced expression of a tumor suppressor gene called Krüppel-like factor 10 (KLF10) is found in breast, lung and pancreatic cancers. KLF10 deficiency in pancreatic cancer is linked to accelerated cancer progression and metastasis, but the underlying mechanisms are unclear. In experiments on mouse models and human cell cultures, Hui-Ju Ch’ang at the National Institute of Cancer Research in Zhunan, Taiwan, ...
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
In this study, chemopreventive effects of O-Hexadecyl- γ-glutamyl-S-benzyl-cysteinyl-D-phenyl glycine-Ethylester (HGBPE), which we previously synthesized to inhibit GSTP1 activity, was analyzed for its effect on the prevention of a rat pancreatic carcinogenesis model induced by 7,12-dimethyl-benzanthracene (DMBA). Rats administered with DMBA were group ed into five cohorts. In the treated group I, which was treated neither with HGBPE nor vehicle, sequential appearance of precancerous lesions, ductal complexes, and adenocarcinoma was confirmed as previously reported. We also confirmed in this group that mutations of K...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
iane J. Bruns Felix C. Popp In pancreatic ductal adenocarcinoma (PDAC), the tumor stroma constitutes most of the cell mass and contributes to therapy resistance and progression. Here we show a hitherto unknown metabolic cooperation between pancreatic stellate cells (PSCs) and tumor cells through Interleukin 17B/Interleukin 17B receptor (IL-17B/IL-17RB) signaling. Tumor-derived IL-17B carrying extracellular vesicles (EVs) activated stromal PSCs and induced the expression of IL-17RB. PSCs increased oxidative phosphorylation while reducing mitochondrial turnover. PSCs activated tumor cells in a feedback loop. Tumor cell...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
CONCLUSIONS: These findings underscore the importance of maintaining good metabolic health in reducing the burden of gastrointestinal cancers, irrespective of genetic predisposition.PMID:34687971 | DOI:10.1016/j.cgh.2021.10.016
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
In conclusion, TPS levels increase late in PDAC progression and hold no potential as a biomarker for early detection.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Neoadjuvant chemotherapy (NAC) is being utilized more frequently in patients with pancreatic adenocarcinoma (PDAC). Not all patients can tolerate modern multiagent regimens due to toxicity profiles or pre-existing comorbidities. We utilized institutional data and the National Cancer Database (NCDB) to investigate if the time from diagnosis to NAC start is associated with survival from surgery for PDAC.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Hepatobiliary and Pancreas Source Type: research
Pancreatic adenocarcinoma is the fourth leading cause cancer-related death. Previous studies have recognized that a high proportion of patients with localized cancer were not undergoing surgical resection. Our study aimed to examine the factors associated with pancreatic surgical intervention to identify opportunities for targeted improvement.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Hepatobiliary and Pancreas Source Type: research
Pancreatic ductal adenocarcinoma (PDAC) is associated with increased venous thromboembolism (VTE). We  sought to compare rates of VTE and bleeding complications in patients receiving extended postoperative thromboprophylaxis (EPT) to those who did not, and to identify factors associated with increased VTE risk after pancreatic resection for PDAC.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Hepatobiliary and Pancreas Source Type: research
More News: Adenocarcinoma | Cancer | Cancer & Oncology | Pancreas | Pancreatic Cancer | Study | Training | Universities & Medical Training