Vertical parasagittal hemispherotomy: a case report of postoperative mesio-temporal seizures via amygdalofugal pathway

We present the case of a girl who underwent VPH for hemimegalencephaly in early infancy. Postoperatively, she developed unexpected seizures of mesio-temporal origin. Stereo-EEG provided arguments for an amygdalar origin. High-resolution MRI with tractography confirmed the presence of the amygdalo-fugal pathway to be responsible of epileptic discharges propagation. She became seizure-free after temporal resection.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research

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CONCLUSIONS: The endoscopic methods allow the total removal of a third ventricle colloid cyst in most patients. Leaving a small coagulated fragment of the cyst rarely results in its recurrence. This method results in effective treatment with a low complications rate, shortens hospitalization time and brings the patient a high level of satisfaction with a quick recovery.PMID:34691312 | PMC:PMC8512511 | DOI:10.5114/wiitm.2021.103957
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Authors: Source Type: research
Conclusions: FC networks associated with the frontal cortex were involved in the termination of absence seizures. The topological properties of FC networks in different frequency bands could be used as new biomarkers to characterize the dynamics of FC networks related to seizure termination.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: This review highlights the need for further high-quality international consensus-based treatment guidelines for LGS, DS, and particularly for CDD (for which no treatment guidelines were identified). Supra-national consensus guidance based on findings from a wider geographical range may improve resource allocation and establish an improved world-wide standard of care.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Anxiety and depression status are common in caregivers of children with epilepsy, with depression status being more prominent. Moreover, a considerable proportion of caregivers had poor sleep quality and unhealthy family function. The caregivers' anxiety status, sleep quality, family role dimension, family general function dimension, and the number of co-caregivers were predictors of depression status in caregivers. In clinical practice, caregivers' anxiety and depression status, poor sleep quality, and unhealthy family functioning should be addressed along with the treatment of children with epilepsy.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
An emotion is the subjective experience of a mental state that directs our attention, guides our actions and is often accompanied by physiological and behavioral changes [1 –3]. Traditional ideas of conversion and dissociation and more recent explanatory models based on emotion processing have linked Psychogenic Nonepileptic Seizures (PNES) closely with emotions [4]. In support of these theories, experimental studies have demonstrated abnormalities of emotion sensiti vity, intensity, perception, tolerance, regulation and baseline arousal when comparing patients with PNES to those with epilepsy, healthy controls, or c...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
In Reply Das et al make important points about the clinical implications of adult-onset attention-deficit/hyperactivity disorder (ADHD), including ADHD after a traumatic brain injury (TBI). It is worth noting that, while useful descriptively, the diagnosis of ADHD provides little insight into the pathobiology that underlies ADHD symptoms. That a substantial number of patients with histories of severe TBI in our article presented with the same ADHD symptoms as children with primary ADHD without histories of TBI underscores this point. As Yeates et al noted in the editorial accompanying our article, “Secondary ADHD is&...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
Int J Dev Neurosci. 2021 Oct 22. doi: 10.1002/jdn.10153. Online ahead of print.ABSTRACTNeurological and neuronal disorders are associated with structural, biochemical, or electrical abnormalities in the nervous system. Many neurological diseases have not yet been discovered. Interventions used for the treatment of these disorders include avoidance measures, lifestyle changes, physiotherapy, neurorehabilitation, pain management, medication, and surgery. In the sodium channelopathies, alterations in the structure, expression, and function of voltage-gated sodium channels (VGSCs) are considered as the causes of neurological a...
Source: International Journal of Developmental Neuroscience - Category: Neuroscience Authors: Source Type: research
Management of women with epilepsy (WWE) during pregnancy requires balancing the risk of seizure recurrence against the adverse effect of anti-epileptic drugs (AED) on the women and foetus. The risk of major congenital malformations (MCMs) is relatively higher in AED exposed women (4% - 9%) as compared to the rate in the general population of women in the reproductive age in the United Kingdom (2.13%)[1] and other high income countries. . Hospital based MCM rate for unselected pregnancies in urban area in western India was 2.31% (1.71-3.10).
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
It has caused me the greatest trouble, and for ever causes me the greatest trouble, to perceive that unspeakably more depends upon what things are called, than on what they are. ” – Friedrich Nietzsche, Die Fröhliche Wissenschaft, Book II, section 581(p97)
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
AbstractIn the field of computational epilepsy, neural field models helped to understand some large-scale features of seizure dynamics. These insights however remain on general levels, without translation to the clinical settings via personalization of the model with the patient-specific structure. In particular, a link was suggested between epileptic seizures spreading across the cortical surface and the so-called theta-alpha activity (TAA) pattern seen on intracranial electrographic signals, yet this link was not demonstrated on a patient-specific level. Here we present a single patient computational study linking the se...
Source: Journal of Computational Neuroscience - Category: Neuroscience Source Type: research
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