How alcohol affects insulin-like growth factor-1 influences at the onset of puberty: A critical review

Alcohol Clin Exp Res. 2021 Sep 15. doi: 10.1111/acer.14711. Online ahead of print.ABSTRACTAlcohol (ALC) is capable of delaying signs associated with pubertal development in laboratory animals, as well as in humans. The normal onset of puberty is the result of a timely increase in gonadotropin-releasing hormone (GnRH) secretion, an action associated with a gradual decline in prepubertal inhibitory influences, while at the same time establishing excitatory inputs to increase release of the peptide to drive the pubertal process. In recent years, insulin like growth factor-1 (IGF-1) has emerged to play a pivotal role in prepubertal GnRH secretion and pubertal development, and ALC abuse has been shown to interfere with the critical actions of the IGF-1 peptide. This review will describe the neuroendocrine research demonstrating the importance of IGF-1 to pubertal development, as well as describing the detrimental effects and mechanisms of action of ALC on the onset and progression of pubertal maturation.PMID:34523716 | DOI:10.1111/acer.14711
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research