The non-canonical mechanism of ER stress-mediated progression of prostate cancer

CONCLUSIONS: We found that progression of PCa associates with translocation of S1P and S2P proteases to the ER and subsequent ATF6 cleavage. This obviates the need for ATF6 transport to the Golgi and enhances UPR and cell proliferation. Thus, we provide the novel mechanistic model of ATF6 activation and ER stress implication in the progression of PCa, suggesting ATF6 is a novel promising target for prostate cancer therapy.PMID:34521429 | DOI:10.1186/s13046-021-02066-7

Source: Cell Research - September 15, 2021 Category: Cytology Authors: Artem N Pachikov Ryan R Gough Caroline E Christy Mary E Morris Carol A Casey Chad A LaGrange Ganapati Bhat Anatoly V Kubyshkin Iryna I Fomochkina Evgeniya Y Zyablitskaya Tatiana P Makalish Elena P Golubinskaya Kateryna A Davydenko Sergey N Eremenko Jean-J Source Type: research