Endogenous Candida endophthalmitis: has it been discerned from a cotton wool spot in the retina?

I read the paper by Seidelman et al with great interest and concern.1 The authors hypothesize that a variety of risk factors may predict the development of endophthalmitis in the setting of Candida septicemia with potential for guiding ophthalmologic screening. However, the data and interpretation presented demonstrate severe flaws that prohibitively limit their conclusions, including but not limited to inaccurate disease classification, selection bias, lack of control for confounding variables, lack of visual outcomes data, any details regarding changes in management based on ocular findings, lack of microbial confirmation from ocular tissue, and lack of a control group for comparison.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research