Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor

ConclusionThe results suggest that megestrol acetate is a specific inducer of CYP3A4 mediated by hPXR and therefore has the potential to cause drug interactions, especially in the co-administration with drugs that are substrates of CYP3A4.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research