Viruses, Vol. 13, Pages 1844: Kinetics of Nucleocapsid, Spike and Neutralizing Antibodies, and Viral Load in Patients with Severe COVID-19 Treated with Convalescent Plasma

Viruses, Vol. 13, Pages 1844: Kinetics of Nucleocapsid, Spike and Neutralizing Antibodies, and Viral Load in Patients with Severe COVID-19 Treated with Convalescent Plasma Viruses doi: 10.3390/v13091844 Authors: Thomas P. Thomopoulos Margherita Rosati Evangelos Terpos Dimitris Stellas Xintao Hu Sevasti Karaliota Anthi Bouchla Ioannis Katagas Anastasia Antoniadou Andreas Mentis Sotirios G. Papageorgiou Marianna Politou Jenifer Bear Duncan Donohue Anastasia Kotanidou Ioannis Kalomenidis Eleni Korompoki Robert Burns Maria Pagoni Elisavet Grouzi Stavroula Labropoulou Kostantinos Stamoulis Aristotelis Bamias Sotirios Tsiodras Meletios-Athanasios Dimopoulos George N. Pavlakis Vasiliki Pappa Barbara K. Felber COVID-19 is an ongoing pandemic with high morbidity and mortality. Despite meticulous research, only dexamethasone has shown consistent mortality reduction. Convalescent plasma (CP) infusion might also develop into a safe and effective treatment modality on the basis of recent studies and meta-analyses; however, little is known regarding the kinetics of antibodies in CP recipients. To evaluate the kinetics, we followed 31 CP recipients longitudinally enrolled at a median of 3 days post symptom onset for changes in binding and neutralizing antibody titers and viral loads. Antibodies against the complete trimeric Spike protein and the receptor-binding domain (Spike-RBD), as well as against the complete Nucleocapsid pro...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research

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Ann Behav Med. 2021 Oct 19:kaab081. doi: 10.1093/abm/kaab081. Online ahead of print.ABSTRACTBACKGROUND: The prevalence and prognosis of post-acute stage SARS-CoV-2 infection fatigue symptoms remain largely unknown.AIMS: We performed a systematic review to evaluate the prevalence of fatigue in post-recovery from SARS-CoV-2 infection.METHOD: Medline, Embase, PsycINFO, CINAHL, Web of Science, Scopus, trial registries, Cochrane Central Register of Controlled Trials, and Google Scholar were searched for studies on fatigue in samples that recovered from polymerase chain reaction (PCR) diagnosed COVID-19. English, French, and Spa...
Source: Annals of Behavioral Medicine - Category: Psychiatry & Psychology Authors: Source Type: research
ConclusionsThe COVID-19 pandemic has placed huge pressures on health services and their delivery across the globe. This theme has extended into international surgical collaborations leading to increased unmet surgical needs in low- and middle-income countries.Level of evidence: Not gradable.
Source: European Journal of Plastic Surgery - Category: Cosmetic Surgery Source Type: research
CONCLUSIONS: This review provides a comprehensive framework and synthesis of a range of non-pharmacological measures implemented in long-term care facilities. These may prevent SARS-CoV-2 infections and their consequences. However, the certainty of evidence is predominantly low to very low, due to the limited availability of evidence and the design and quality of available studies. Therefore, true effects may be substantially different from those reported here. Overall, more studies producing stronger evidence on the effects of non-pharmacological measures are needed, especially in low- and middle-income countries and on p...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
MMWR Morb Mortal Wkly Rep. 2021 Sep 10;70(36):1255-1260. doi: 10.15585/mmwr.mm7036e2.ABSTRACTAlthough COVID-19-associated hospitalizations and deaths have occurred more frequently in adults,† COVID-19 can also lead to severe outcomes in children and adolescents (1,2). Schools are opening for in-person learning, and many prekindergarten children are returning to early care and education programs during a time when the number of COVID-19 cases caused by the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19, is increasing.§ Therefore, it is important to monitor indicators...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Source Type: research
Having trouble viewing this email? View it as a Web page. NIDCR's Fall 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities &Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   NIDCR News 5 Q&As About “Oral Health in America: Advances and Challenges” NIDCR issued a brief Q&A regarding details of the forthcoming report Oral Health in America: Advances and Challenges, which will be published in Fall 2021. This comprehensive report will examine improvements in oral health over the past t...
Source: NIDCR Science News - Category: Dentistry Source Type: news
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