Molecular and cellular characterization of pyoderma gangrenosum: Implications for the use of gene expression

Pyoderma gangrenosum (PG) is characterized by painful ulcers typically affecting the lower extremities. PG pathogenesis and triggers are poorly understood (Ortega- Loayza AG et al., 2018). Treatments target systemic inflammation, but clinical response and outcomes remain unpredictable. Further investigations are necessary to understand PG pathobiology; however, little is known about gene expression in PG, including whether important changes localize to the dermis or epidermis and whether non-lesional skin from PG patients shows subclinical signs of disease.

Source: Journal of Investigative Dermatology - September 15, 2021 Category: Dermatology Authors: Alex G. Ortega-Loayza, Marcia A. Friedman, Ashley M. Reese, Yuangang Liu, Teri M. Greiling, Pamela B. Cassidy, Angelo V. Marzano, Lina Gao, Suzanne S. Fei, James T. Rosenbaum Tags: Letters to the Editor Source Type: research