The Effects of COVID-19 on the Placenta During Pregnancy

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregnancy-related complications in SARS-CoV-2 positive mothers, such as miscarriage, restricted fetal growth, or still-birth. In this review, we discuss the pathobiology of COVID-19 maternal infection and the potential adverse effects associated with viral infection, and the possibility of transplacental transmission.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
ConclusionsOlanzapine use is associated with an increased risk of major congenital malformations and specifically, musculoskeletal malformations. Use during pregnancy should be restricted to situations where no safer alternatives exist.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study aimed to understand the extent to which cannabis-related risk perception and COVID-19-related health worries were associated with the reported reduction in sharing cannabis smoking products to mitigate the risk of the coronavirus transmission or infection. This association was tested in two different periods in terms of toughness of national lockdown policy imposed in the first months of the pandemic in Israel. The study population included adult recreational cannabis users who completed one of the two online cross-sectional surveys dedicated to COVID-19 and the cannabis use situation in Israel in the first h...
Source: Drugs and Alcohol Today - Category: Addiction Authors: Source Type: research
AbstractSTUDY QUESTIONWhat is the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the outcome of a pregnancy after medically assisted reproduction (MAR)?SUMMARY ANSWEROur results suggest that MAR pregnancies are not differentially affected by SARS-CoV-2 infection compared to spontaneous pregnancies.WHAT IS KNOWN ALREADYInformation on the effects of coronavirus disease 2019 (COVID-19) on pregnancy after MAR is scarce when women get infected during MAR or early pregnancy, even though such information is vital for informing women seeking pregnancy.STUDY DESIGN, SIZE, DURATIONData from SARS-...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
ConclusionsThere is an increased risk of abortion in mothers with a positive test result of SARS-CoV-2, which several case reports and case series have identified during the pandemic. Placental inflammation during the viral infection may result in fetal growth retardation and induce abortion. There has not been any consistent evidence of vertical transmission of the virus from mother to fetus, which requires further investigation.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
AbstractStudy questionUnder deadly pandemic conditions involving the novel SARS-CoV –2 corona virus, could biopsied blastocysts be safely cryopreserved, stored and utilized for subsequent warming cycles?Summary answerBlastocysts were securely stored, effectively warmed and safely transferred to yield normal pregnancy outcomes under uncertain laboratory conditions subject to unprecedented policy changes.What is known alreadyBy April 2020, every IVF lab worldwide was implementing deep cleaning/disinfecting procedures in their laboratory and patient-contact areas, thorough hand-washing policies and mandatory PPE to redu...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Rather a gap since the last one.  Apologies for that.First two things relating to COVID.  The Nuffield Trust have investigatedadverse outcomes for babies born during the pandemic.  And ascoping review about vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2.And other research.  A systematic review of the maternal, fetal, and child outcomes of mental health treatments in women, from the Agency for Healthcare Research and Quality in the USA.  ARCT of delivery mode after manual rotation of occiput posterior fetal positions. Two Cochrane reviews: ...
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
Abstract SARS-CoV-2 virus was first identified in the beginning of 2020 and has spread all over the world, causing the Coronavirus Disease 2019 (COVID-19) pandemic. The virus is a member of the Coronavirus family, which includes viruses that cause common cold, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). MERS and SARS are known by causing adverse events in pregnancy. Considering that SARS-CoV-2 is a new infection agent, little is known about the risk of its infection to human embryo/fetal development. However, SARS and MERS were associated with negative outcomes, such as miscarriage...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
More than 130 million women give birth around the world each year. During pregnancy, changes in the immune system make women generally more susceptible to respiratory infections. And this year, pregnant women also have to worry about COVID-19, a virus that can affect a person’s lungs and airways. The U.K. government announced on Monday that pregnant women were at an increased risk of severe illness from coronavirus (COVID-19). Speaking at a press conference, Public Health England chief medical officer Chris Whitty said people in the “high risk” category should stay at home for 12 weeks. (That includes pe...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Explainer Londontime Source Type: news
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