Persistent Hypoglycemia Induced by Long-acting Insulin Degludec

Intern Med. 2021 Sep 4. doi: 10.2169/internalmedicine.7915-21. Online ahead of print.ABSTRACTA 58-year-old Japanese man was brought to the emergency room due to disturbance of consciousness. He regained consciousness on the day of admission and started taking hospital meals, but he needed intravenous glucose administration for eight days. The total amount of glucose administration was 4,464 g. It took over three weeks for exogenous insulin to be almost undetectable. While degludec binds to albumin and exerts glucose-lowering effects for a long time, the above-mentioned period of three weeks was consistent with the half-life of albumin. Hypoglycemia induced by massive dose of insulin degludec is persistent and prominent.PMID:34483209 | DOI:10.2169/internalmedicine.7915-21

Source: Internal Medicine - September 6, 2021 Category: Internal Medicine Authors: Yukino Katakura Fuminori Tatsumi Takashi Kusano Masashi Shimoda Kenji Kohara Tomohiko Kimura Atsushi Obata Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto Source Type: research