Aleukemic Extramedullary Blast Crisis as an initial presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript

Intern Med. 2021 Sep 11. doi: 10.2169/internalmedicine.8319-21. Online ahead of print.ABSTRACTRight neck swelling and pain occurred in a 49-year-old man. A Blood count showed a slight increase in platelet count without leukemoid reaction. After a biopsy of the cervical mass and bone marrow aspiration, a diagnosis of extramedullary blast crisis (EBC) of chronic myeloid leukemia (CML) was made. FISH analysis showed a BCR-ABL1 fusion signal, but results of RT-PCR for major and minor BCR-ABL1 transcripts were negative. We identified a rare e1a3 BCR-ABL1 fusion transcript. Administration of dasatinib resulted in disappearance of the extramedullary tumor. This is the first reported case of CML-EBC with e1a3 transcript. An aleukemic extramedullary tumor can be the initial presentation of CML.PMID:34511573 | DOI:10.2169/internalmedicine.8319-21

Source: Internal Medicine - September 13, 2021 Category: Internal Medicine Authors: Naoki Miyashita Masahiro Onozawa Keito Suto Shinichi Fujisawa Nanase Okazaki Daisuke Hidaka Hiroyuki Ohigashi Atsushi Yasumoto Junichi Sugita Daigo Hashimoto Yoshihiro Matsuno Takanori Teshima Source Type: research