Direct Blood Pressure-Independent Anti-Fibrotic Effects by the Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone in Progressive Models of Kidney Fibrosis
CONCLUSION: Finerenone has direct anti-fibrotic properties resulting in reduced myofibroblast and collagen deposition accompanied by a reduction in renal PAI-1 and NKD2 expression in mouse models of progressive kidney fibrosis at blood pressure-independent dosages.PMID:34515038 | DOI:10.1159/000518254
New J. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1NJ03836B, PaperMarzieh Hamidzadeh, Mohadese Nazari, Maryam Rahimi Fard We investigated the effects of different sources of alumina (Pseudo-boehmite, Aluminum hydroxide, Aluminum tri-sec-butylate, Aluminum isopropoxide, and Aluminum phosphate) and silica (Silica sol, Silicic acid, Tetraethyl orthosilicate, and sodium silicate)... The content of this RSS Feed (c) The Royal Society of Chemistry
Cardiac ischemia includes severe damage to heart muscle tissue due to decreased or cessation of blood flow, which involves failure to supply nutrients and oxygenation to heart cells. Causes can include blockages due to fat and cholesterol deposits. These damages include cell apoptosis, calcium and sodium concentration imbalance, loss of contraction force, and formation of reactive oxygen spe...
Analysis of Medicare data supports findings from younger adults that use of the drug class does not appear to raise fracture risk.Medscape Medical News
In the first human subject, insulin requirement dropped by 91% at 90 days.Medscape Medical News
EARLY warning signs of high blood sugar - a prerequisite for diabetes - can easily be mistaken for a viral infection or another illness. This is why experts from Diabetes UK want everyone to be aware of the "4Ts".
Condition: Diabetes Mellitus, Type 1 Intervention: Device: YpsoPump® insulin pump system Sponsors: Ypsomed AG; Diabetes Center Berne Research AG Not yet recruiting
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Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition–An Outstanding Challenge Attila Fintha1, Ákos Gasparics2, László Rosivall3 and Attila Sebe3,4* 12nd Department of Pathology, Semmelweis University, Budapest, Hungary 21st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary 3Department of Pathophysiology, International Nephrology Research and Training Center, Semmelweis University, Budapest, Hungary 4Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany Back in 1995, a landmark paper was published, which shaped the fi...
Publication date: Available online 9 March 2018 Source:Pharmacological Research Author(s): Ya-Kun Li, Dong-Xia Ma, Zhi-Min Wang, Xiao-Fan Hu, Shang-Lin Li, Hong-Zhe Tian, Meng-Jun Wang, Yan-Wen Shu, Jun Yang Renal fibrosis is recognized as the common route of all chronic kidney disease (CKD) progressing to end-stage renal disease (ESRD). Additionally, accumulating evidence suggests that epithelial-mesenchymal transition (EMT) plays a significant role in the process of renal fibrogenesis. Liraglutide is a long-acting glucagon-like peptide-1 (GLP-1) analog that has been widely used to treat type 2 diabetes. Recent studies h...