Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis Immunology and Inflammation

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin dryness, inflammation, and itch. A major hallmark of AD is an elevation of the immune cytokines IL-4 and IL-13. These cytokines lead to skin barrier disruption and lipid abnormalities in AD, yet the underlying mechanisms are unclear. Sebaceous...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Immunology and Inflammation Biological Sciences Source Type: research

Related Links:

J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-503. Online ahead of print.ABSTRACTApalutamide, an oral androgen receptor signaling inhibitor, is approved for the treatment of non-metastatic castration-resistant prostate cancer and metastatic prostate cancer. In the international randomized placebo-controlled clinical trials, apalutamide was associated with a higher rate of rash than placebo. However, given that reports from a dermatological perspective are limited, the skin manifestations and histopathology of the skin lesions caused by apalutamide are largely unknown. Here, we report a case of apalutamide-i...
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Source Type: research
Acta Derm Venereol. 2021 Sep 13. doi: 10.2340/00015555-3922. Online ahead of print.ABSTRACTThe aim of this study was to detect demographic and clinical factors associated with affective symptoms and quality of life in patients with severe atopic dermatitis. First, one-way analyses of variance and correlations were performed to compare a large set of qualitative and quantitative clinical variables. Three final multivariable regression models were performed, with depression/anxiety subscales and Dermatology Life Quality Index scores as dependent variables, and the factors that were statistically significant on univariate ana...
Source: Acta Derm Venereol A... - Category: Dermatology Authors: Source Type: research
ConclusionsIn the present case, we hypothesized that idiopathic hypereosinophilic syndrome was the likely cause of the atopic dermatitis and small-fiber neuropathy, consistent with pain and dysautonomic symptoms.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: CASE REPORT Source Type: research
If you've ever experienced a red, itchy rash appear on your skin after using a certain lotion or even from wearing jewelry, you may be experiencing contact dermatitis. It's caused by a substance you're exposed to that irritates your skin. However, it also can be triggered by an allergic reaction.In this Mayo Clinic Minute, Dr. Matthew Hall, a Mayo Clinic dermatologist, explains how patch testing is crucial to assess for allergic contact dermatitis. Watch: The…
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
Pruritus is a common symptom of dermatological disorders and has a major negative impact of quality of life. Previously, it was suggested that skin derived β-defensin peptides elicit itch through activation of mast cells. Here we investigated, in more detail, the mechanisms by which β-defensins induce itch by defining the receptors activated by these peptides in humans and mice, by establishing their action in vivo, and examining their expression in dermal diseases. We found in psoriasis and atopic dermatitis, elevated expression of DEFB103 is highly correlated with skin lesions.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
The objective of this study was to delineate the diagnostic criteria for this disease. A PubMed search was performed for: "prurigo simplex", "prurigo simplex subacuta", "subacute prurigo", "chronic papular dermatitis in adults" and "itchy red bump disease". Medical charts of patients with prurigo diagnoses in a university setting were analysed. The literature search revealed 32 relevant studies (431 patients) on different aspects of the disease. Out of 50 patients with prurigo diagnoses, 5 patients (4 women, mean age at onset 54 years) met the description in literature. Sma...
Source: Acta Derm Venereol A... - Category: Dermatology Authors: Source Type: research
More News: Academies | Allergy & Immunology | Dermatitis | Dermatology | Hormones | Itchiness | Science | Skin