Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis [Immunology and Inflammation]

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin dryness, inflammation, and itch. A major hallmark of AD is an elevation of the immune cytokines IL-4 and IL-13. These cytokines lead to skin barrier disruption and lipid abnormalities in AD, yet the underlying mechanisms are unclear. Sebaceous...

Source: Proceedings of the National Academy of Sciences - September 14, 2021 Category: Science Authors: Chenlu Zhang, Mahendran Chinnappan, Courtney A. Prestwood, Marshall Edwards, Methinee Artami, Bonne M. Thompson, Kaitlyn M. Eckert, Goncalo Vale, Christos C. Zouboulis, Jeffrey G. McDonald, Tamia A. Harris-Tryon Tags: Immunology and Inflammation Biological Sciences Source Type: research