Radioresistance and transcriptional reprograming of invasive glioblastoma cells

Infiltrative growth pattern is a hallmark of glioblastoma (GBM). Radiotherapy aims to eradicate microscopic residual GBM cells post-surgical removal of the visible tumor bulk. However, in field recurrences remain the major pattern of therapy failure. We hypothesized that the radiosensitivity of peripheral invasive tumor cells (peri) may differ from predominantly investigated tumor bulk.

Source: International Journal of Radiation Oncology * Biology * Physics - September 14, 2021 Category: Radiology Authors: Zili Tang, Ivana Dokic, Maximilian Knoll, Federica Ciamarone, Christian Schwager, Carmen Klein, Gina Cebulla, Dirk C Hoffmann, Julian Schlegel, Philipp Seidel, Christiane Rutenberg, Stephan Brons, Christel Herold-Mende, Wolfgang Wick, J ürgen Debus, Diet Tags: Biology Contribution Source Type: research