Brexanolone, a GABAA Modulator, in the Treatment of Postpartum Depression in Adults: A Comprehensive Review

Postpartum depression (PPD) is one of the three major categories on the spectrum of postpartum psychiatric syndromes. Postpartum psychiatric syndromes are classified as either postpartum blues, postpartum depression, or postpartum psychosis. Postpartum depression is important to recognize clinically because of the effect it can have on the mother-child bond. The neurosteroid allopregnanolone, a progesterone derivative, is important for its role in positively modulating GABAA receptors. GABA-mediated signaling has been previously implicated in major depressive disorder. Allopregnanolone-mediated signaling has been identified as an important therapeutic target. Treatment with an allopregnanolone-analog, brexanolone, has been shown to improve depression scores in trials for the treatment of PPD. Brexanolone is a positive allosteric modulator of GABAA and is the first drug approved by the FDA to treat postpartum depression. Brexanolone enhances the inhibitory effects of GABAA, restores dysfunctional GABAA transmembrane channels, and mimics a naturally produced progesterone metabolite that fluctuates during pregnancy and postpartum. One open-label study and two phase two studies have some significant reduction in HAM-D scores after treatment and that the effect was still there 30 days post-treatment. Per the data reported, intravenous infusion of brexanolone could be efficacious and safe for the treatment of women suffering from postpartum depression.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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In this study, 480 cases of normal primiparas who had regular prenatal examination and delivered in hospital were selected as the research object. The Hospital Anxiety and Depression Scale (HAD) was used to record the depressive anxiety state of all study subjects in the third trimester, and we analyzed the effects of age, education background of pregnant women and their spouses, the nature of jobs, family income, prenatal and pregnancy health status, medical insurance status, attend pregnant women's school, and accompanying status of family member on their depressive anxiety state. The influence of depression and anxiety ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
CONCLUSIONS: We describe potential psychological risk factors to maternal-infant bonding among postpartum women during the pandemic period. To best support the medical and psychological well-being of the mothers and infants, enhanced interdisciplinary partnerships among perinatal healthcare professionals involved in primary and/or specialty care is needed.IMPACT: Unique COVID-19-related health and grief concerns exist, with implications for maternal-infant bonding. Depression but not anxiety is associated with lower maternal-infant bonding. Caregiving confidence, but not social support, is associated with higher maternal-i...
Source: Pediatric Research - Category: Pediatrics Authors: Source Type: research
CONCLUSIONS: Perinatal women reported decreased social support during the COVID-19 pandemic which was associated with poorer mental health. Using virtual means of social support and support provided by friends had the largest positive effect on perceived social support levels.IMPLICATIONS FOR PRACTICE: Interventions using virtual support means from friends may be helpful to improve social support and mental health in this population.PMID:34649034 | PMC:PMC8485715 | DOI:10.1016/j.midw.2021.103162
Source: Midwifery - Category: Midwifery Authors: Source Type: research
CONCLUSIONS: We describe potential psychological risk factors to maternal-infant bonding among postpartum women during the pandemic period. To best support the medical and psychological well-being of the mothers and infants, enhanced interdisciplinary partnerships among perinatal healthcare professionals involved in primary and/or specialty care is needed.IMPACT: Unique COVID-19-related health and grief concerns exist, with implications for maternal-infant bonding. Depression but not anxiety is associated with lower maternal-infant bonding. Caregiving confidence, but not social support, is associated with higher maternal-i...
Source: Pediatric Research - Category: Pediatrics Authors: Source Type: research
AbstractAlthough prior research has examined associations between blood pressure (BP), depression, and suicidal ideation, few studies have examined this in high-risk populations such as pregnant women with HIV (WHIV). The current study examined the association of BP with depression and suicidal ideation among pregnant WHIV (n  = 217) in rural South Africa. BP data (measured ≤ 1 month before the study visit) was extracted from medical records. Depressive symptomatology and suicidal ideation were assessed using the Edinburgh Postnatal Depression Scale. Diastolic BP was positively associate...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
OBJECTIVEs Barriers to in-person mental health care are common in pregnant and postpartum women with depression. We assessed the feasibility of a trial protocol for evaluating the use of secure, in-home synchronous virtual psychiatric care. Methods In ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
CONCLUSIONS: This study suggests that mothers with asthma are not at an increased risk for excessive parenting stress. However, due to response and sampling bias, levels of parenting stress in asthmatic mothers may be underreported in our sample.PMID:34641750 | DOI:10.1080/02770903.2021.1993246
Source: Journal of Asthma - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSION: Our study indicates that pregnant women with a history of depression have increased markers of immune system function and their offspring show behavioural alterations that may be the effects of in utero programming, epigenetic factors or genetic predisposition.PMID:34644586 | DOI:10.1016/j.bbi.2021.09.020
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Source Type: research
CONCLUSIONS: This study suggests that mothers with asthma are not at an increased risk for excessive parenting stress. However, due to response and sampling bias, levels of parenting stress in asthmatic mothers may be underreported in our sample.PMID:34641750 | DOI:10.1080/02770903.2021.1993246
Source: Journal of Asthma - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSION: Our study indicates that pregnant women with a history of depression have increased markers of immune system function and their offspring show behavioural alterations that may be the effects of in utero programming, epigenetic factors or genetic predisposition.PMID:34644586 | DOI:10.1016/j.bbi.2021.09.020
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Source Type: research
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