Stiff Person Syndrome and Prior Temporal Lobectomy: Is It a Case of Misplaced Autoimmunity?

ConclusionThe diagnosis of SPS can get delayed in a patient with history of epilepsy. Although SPS and epilepsy are often linked by anti-GAD antibodies as common etiology, it is possible that epilepsy surgery might be a trigger for development of SPS in a small subset. Development of autoimmunity to neuronal GAD65 protein, exposed during surgery, is suspected in pathogenesis.

https://onlinelibrary.wiley.com/doi/10.1111/cen3.12675?af=R

Source: Clinical and Experimental Neuroimmunology - September 14, 2021 Category: Neurology Authors: Ahmed Babiker, Sohum Trivedi, Klepper Alfredo Garcia, Manan Shah Tags: CASE REPORT Source Type: research