Development of a multiplex immuno-oncology biomarker and digital pathology workflow for assessment of urothelial carcinoma
CONCLUSIONS: m-IHC offers significant advantages in characterizing the host immune microenvironment particularly in limited biopsy tissue material. Utilizing a digital image workflow resulted in significant concordance between m-IHC and individual single stains (p < 0.001 for all assessments). Moderate to good agreements were achieved between manual and digital scoring. Our technical work demonstrated potential uses of multiplex marker in assessing the host immune status and could be used in conjunction with PD-L1 as a predictor of response to ICI therapy.PMID:34509050 | DOI:10.1016/j.prp.2021.153607
Source: Pathology, Research and Practice - Category: Pathology Authors: Youheng Xie Ekaterina Olkhov-Mitsel Samira Alminawi Elzbieta Slodkowska Michelle R Downes Source Type: research