‘A very cruel exit’: UK’s aid cuts risk rapid return of treatable diseases

£200m project to eliminate avoidable blindness and disfigurement in Africa ends after funding is prematurely axedA chandelier sparkling in the background, the grandeur of Downing Street gleaming behind him, Boris Johnson looks into the camera and speaks with solemnity. He is marking World Neglected Tropical Diseases Day, he says, to raise awareness of these “terrible afflictions … which impose an immense burden of suffering in developing countries”.Huge progress has been made, he says, in the fight against the diseases, not least as a result of British aid to some of the poorest parts of the world. But there is more – much more – to be done: more than a billion people are still at risk, he warns, and that is why the UK “fully supports” the World Health Organization’sbig elimination push over the next decade.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Global development Infectious diseases Medical research Microbiology Science Africa Aid World news Blindness and visual impairment Health Source Type: news

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A Raleigh-based gene therapy startup that's tackling blindness has filled two leadership roles shortly after raising $19 million in seed financing.
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
CONCLUSIONS: Results of our study support the hypothesis that D-allele and DD-genotype of rs35569394 have deleterious effect on the progression of DR. C-allele had skewed frequency towards DR III subjects owing to strong linkage disequilibrium between C-allele (rs699947) and D-allele (rs35569394).PMID:34693874 | DOI:10.1080/13816810.2021.1992786
Source: Ophthalmic Genetics - Category: Opthalmology Authors: Source Type: research
J Immunol Res. 2021 Oct 14;2021:2389029. doi: 10.1155/2021/2389029. eCollection 2021.ABSTRACTDiabetic retinopathy (DR), as a major cause of blindness worldwide, is one common complication of diabetes mellitus. Inflammatory response and oxidative stress injury of endothelial cells play significant roles in the pathogenesis of DR. The study is aimed at investigating the effects of lysophosphatidylcholine (LPC) on the dysfunction of high glucose- (HG-) treated human retinal microvascular endothelial cells (HRMECs) after being cocultured with bone marrow mesenchymal stem cells (BMSCs) and the underlying regulatory mechanism. C...
Source: Journal of Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
Age-related macular degeneration (AMD) is a leading cause of blindness. Late AMD can be classified into exudative (commonly known as wet AMD [wAMD]) or dry AMD, both of which may progress to macular atrophy (MA). MA causes irreversible vision loss and currently has no approved pharmacological treatment. The standard of care for wAMD is treatment with anti-vascular endothelial growth factors (VEGF). However, recent evidence suggests that anti-VEGF treatment may play a role in the development of MA. Therefore, it is important to identify risk factors for the development of MA in patients with wAMD. For example, excessive blo...
Source: Ophthalmologica - Category: Opthalmology Source Type: research
Stefania Galdiero HSV infections, both type 1 and type 2, are among the most widespread viral diseases affecting people of all ages. Their symptoms could be mild, with cold sores up to 10 days of infection, blindness and encephalitis caused by HSV-1 affecting immunocompetent and immunosuppressed individuals. The severe effects derive from co-evolution with the host, resulting in immune evasion mechanisms, including latency and growing resistance to acyclovir and derivatives. An efficient alternative to controlling the spreading of HSV mutations is the exploitation of new drugs, and the possibility of enhancing their ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Exp Eye Res. 2021 Oct 21:108800. doi: 10.1016/j.exer.2021.108800. Online ahead of print.ABSTRACTAging is a predominant risk factor for various eye diseases. Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, and its etiology remains unclear. Fragmented and dysfunctional mitochondria are associated with age-related diseases. The retinal pigment epithelium (RPE), a polarized cell layer that functions in visual pigment recycling and degeneration, is suspected as the primary region site of AMD. In the present study, we investigated the relationship between mitochondrial dysfunction and RPE...
Source: Cell Research - Category: Cytology Authors: Source Type: research
DIABETES affects millions of Britons, and if left untreated can cause serious complications, including blindness. Do you know the diabetes symptoms to look out for in your eyes?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Hyaluronic acid filler injection is generally regarded a safe procedure. However, serious ischemic complications do exist, notably blindness and skin necrosis. Hyaluronidase is an enzymatic reversal agent for hyaluronic acid fillers; it is used to treat acute ischemic complications. Unfortunately, many barriers exist for injector sites to stock hyaluronidase, including price, short shelf-life, and complacency given the low incidence of ischemic complications. As a result, emergency rooms (ERs) are often expected to be a safety net in cases when injectors encounter an ischemic complication but have inadequate supplies of hy...
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Plastic and Maxillofacial Surgery Source Type: research
Myopia is a leading cause of visual impairment and blindness worldwide. However, a safe and accessible approach for myopia control and prevention is currently unavailable. Here, we investigated the therapeutic effect of dietary supplements of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on myopia progression in animal models and on decreases...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Medical Sciences Biological Sciences Source Type: research
ConclusionsThe prevalence of T2D has increased during the last decade in Malm ö. There are significant differences in T2D prevalence within the city related to contextual and socioeconomic factors. The highest T2D prevalence occurs in the area with the lower income and lower level of education.Key messagesPromotive actions need to be specifically targeted at younger populations in the city of Malm ö to prevent the increase in type-2 diabetes and its complications.Contextual factors need to be taken into consideration in the development of sustainable primary and secondary preventive actions for type-2 diabetes in...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
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