A Rare Case of Atypical Chronic Myeloid Leukemia Associated with t(8;22)(p11.2;q11.2)/ BCR-FGFR1 Rearrangement: A Case Report and Literature Review.

Originally designated the 8p11 myeloproliferative syndrome, the rare myeloid and/or lymphoid neoplasms characterized by translocations involving the fibroblast growth factor receptor-1 (FGFR1) gene at chromosome 8p11.2, are currently classified by the World Health Organization (WHO) under the term “myeloid/lymphoid neoplasms with FGFR1 rearrangement.1” This diagnostic subgroup is associated with heterogeneous disease manifestations including myeloid hyperplasia with eosinophilia, a high risk of progression to acute myeloid leukemia, and lymph node involvement by T- or B-lymphoblastic lymp homa.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research