Phosphodiesterase-1 inhibitor modulates Ca < sup > 2+ < /sup > regulation in sirtuin 1-deficient mouse cardiomyocytes

CONCLUSIONS: Our results suggest that ITI-214 improves intracellular Ca2+ regulation, which in turn exerts inotropic effects and suppresses arrhythmic events in Sirt1-deficient ventricular myocytes.PMID:34506778 | DOI:10.1016/j.ejphar.2021.174498

Source: European Journal of Pharmacology - September 10, 2021 Category: Drugs & Pharmacology Authors: Hui-Wen Yang Chih-Yuan Lin Feng-Zhi Lin Pei-Ling Yu Shih-Ming Huang Yao-Chang Chen Chien-Sung Tsai Hsiang-Yu Yang Source Type: research