High Expression of Stem Cell-Related Genes in Polyps with Villous Features and High-Grade Dysplasia Support Malignant Phenotype and Colorectal Carcinogenesis
CONCLUSION: This study shows that the increase of SCRGs expressions occurs with high-grade dysplasia (HGD), villous features, and the malignant phenotype. Increased expression levels of LGR5, PROM1, KLF4, SOX2, and MYC in HGD and cancerous tissues support the malignant phenotype and the existence of cancer stem cells and demonstrate that they can be used to assess diagnosis and prognosis. Identification of tissue-specific SCRGs expressions will help design new therapies to control the development and progression of colonic neoplasia.PMID:34452555 | DOI:10.31557/APJCP.2021.22.8.2429
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Authors: Ibrahim Sahin Bet ül Gündoğdu Ahmet Cevdet Ceylan Haktan Bagis Erdem Abdulgani Tatar Source Type: research
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