Electrocatalytic CuBr@CuO nanoparticles based salivary glucose probes

Biosens Bioelectron. 2021 Sep 3;194:113610. doi: 10.1016/j.bios.2021.113610. Online ahead of print.ABSTRACTHighly electrocatalytic cuprous halide/copper oxide nanoparticles (CuX@CunO NPs; X = Cl, Br or I; n = 1 or 2) have been fabricated on copper foils for sensitive detection of glucose. Formation of CuX@CunO NPs involves two steps- in situ electrochemical deposition of CuX on the foil and then conversion of CuX to CunO. The deposited CuX converts to CunO, leading to the generation of abundant oxygen vacancies in the CuO lattice, enhancing the number of catalytically active sites, and improving the charge transfer efficiency. Among the as-prepared electrodes, CuBr@CuO NP ones provide the highest electrocatalytic activity toward the oxidation of glucose. The electrode provides electrocatalytic activity toward the oxidation of glucose at a low overpotential of 0.25 V (vs. SCE), which is lower than that (0.40 V) of unmodified copper electrodes. The generated anodic current is proportional to glucose concentration in an alkaline medium, with a good linear range from 5.0 μM to 3.51 mM (R2 = 0.995). Its reliability has been validated by detecting the glucose concentration in saliva samples at different time intervals after a meal. The results are in good correlation with the blood glucose level determined by using a commercial blood glucose meter. Our CuBr@CuO NP electrode possesses great potential for monitoring salivary glucose to achieve the purpose of noninvasive glucose moni...
Source: Biosensors and Bioelectronics - Category: Biotechnology Authors: Source Type: research