Commentary: Choosing the Right Model for Bile Reflux Induced Esophageal Disease Research

Esophageal cancer has a high mortality and poor prognosis. The incidence of esophageal adenocarcinoma (EAC), the most common form of this cancer in the United States, has dramatically risen in recent years.1 Chronic exposure of the esophagus to gastroduodenal intestinal fluid is an important determinant factor in the development of Barrett's esophagus (BE), which is closely associated with the development of EAC.2 Although the close relationship between bile reflux and EAC has been well established, little is known about the mechanisms that link bile acids to esophageal carcinogenesis due to a lack of reliable models.
Source: Seminars in Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: THORACIC – Commentary Source Type: research