Cancers, Vol. 13, Pages 4580: Hyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies —A Retrospective, Multicentre Study
Cancers, Vol. 13, Pages 4580: Hyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies—A Retrospective, Multicentre Study
Cancers doi: 10.3390/cancers13184580
Authors:
Michael Ried
Julia Kovács
Till Markowiak
Karolina Müller
Gunnar Huppertz
Michael Koller
Hauke Winter
Laura V. Klotz
Rudolf Hatz
Julia Zimmermann
Bernward Passlick
Severin Schmid
Mohamed Hassan
Martin E. Eichhorn
Hans-Stefan Hofmann
In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity (particularly renal insufficiency). A retrospective, multicentre study of patients who underwent cytoreductive surgery (CRS) with cisplatin-based HITOC was performed. The study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation (GZ: RI 2905/3-1)). Patients (n = 350) with malignant pleural mesothelioma (n = 261; 75%) and thymic tumours with pleural spread (n = 58; 17%) or pleural metastases (n = 31; 9%) were analyzed. CRS was accomplished by pleurectomy/decortication (P/D: n = 77; 22%), extended P/D (eP/D: n = 263; 75%) or extrapleural pneumonectomy (EPP: n = 10; 3%). Patients received cisplatin alone (n = 212; 61%) or cisplatin plus doxorubicin (n = 138; 39%). Low-dose cisplatin (≤125 mg/m2 BSA) was given in 67% of patients (n = 234), and high-dose cisplatin (>125 mg/m2 BSA) was given in 33% of patients (n = 116). Postoperative renal insuf...
Source: Cancers - Category: Cancer & Oncology Authors: Michael Ried Julia Kov ács Till Markowiak Karolina M üller Gunnar Huppertz Michael Koller Hauke Winter Laura V. Klotz Rudolf Hatz Julia Zimmermann Bernward Passlick Severin Schmid Mohamed Hassan Martin E. Eichhorn Hans-Stefan Hofmann Tags: Article Source Type: research
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