Structure and function of the important internalins of Listeria monocytogenes

Curr Protein Pept Sci. 2021 Sep 2. doi: 10.2174/1389203722666210902163300. Online ahead of print.ABSTRACTListeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The arsenal of virulence factors employed by L. monocytogenes for its infection cycle is available in the literature. Although the internalins of L. monocytogenes have been studied in detail their structural details are currently scattered and fragmented. Therefore, in the current review, we provide a brief account of the existing knowledge on structural details of the key internalins of L. monocytogenes and also highlight the recent advances in their functional aspects.PMID:34473616 | DOI:10.2174/1389203722666210902163300
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Source Type: research