Chronic Infusions of Mecamylamine into the Medial Habenula: Effects on Nicotine Self-Administration in Rats

This study determined that medial habenular nicotinic receptors are important for nicotine reinforcement. Baseline level of performance makes a crucial difference for the involvement of habenular mechanisms in nicotine reinforcement with nicotinic activation being important for maintaining nicotine self-administration for those with lower levels of baseline self-administration and the opposite effect with subjects with higher levels of baseline self-administration.PMID:34499942 | DOI:10.1016/j.bbr.2021.113574

Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Edward D Levin Corinne Wells Susan Slade Joshua Johnson Ann Petro Amir H Rezvani Jed E Rose Source Type: research