Autoimmunity: Basophils in autoimmune and inflammatory diseases

Nature Reviews Rheumatology 11, 129 (2015). doi:10.1038/nrrheum.2014.199 Authors: Meenu Sharma & Jagadeesh Bayry Basophils are classically known for their pathogenic role in asthma and allergic skin conditions. However, reports suggest that basophil activation mediated by autoreactive IgE, thymic stromal lymphopoietin or Toll-like receptors has an important role in the pathogenesis of lupus nephritis, eosinophilic oesophagitis and IgG4-related diseases, respectively.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Tags: News and Views Source Type: research