Different properties of mammary carcinogenesis induced by two chemical carcinogens, DMBA and PhIP, in heterozygous BALB/c < em > Trp53 < /em > knockout mice

In conclusion, the present mouse mammary carcinogenesis models, induced by a combination of genetic and exogenous factors, may be utilized (such as the DMBA-induced model with Trp53 gene function deficiency as a model of adenomyoepithelioma, characterized by distinct biphasic cell constituents and Hras mutations), but PhIP-induced models are required to further analyze the genetic/epigenetic mechanisms promoting mammary carcinomas.PMID:34466150 | PMC:PMC8387855 | DOI:10.3892/ol.2021.12999
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research