An Updated Model for the Epigenetic Regulation of Effector and Memory CD8 < sup > + < /sup > T Cell Differentiation

J Immunol. 2021 Sep 15;207(6):1497-1505. doi: 10.4049/jimmunol.2100633.ABSTRACTNaive CD8+ T cells, upon encountering their cognate Ag in vivo, clonally expand and differentiate into distinct cell fates, regulated by transcription factors and epigenetic modulators. Several models have been proposed to explain the differentiation of CTLs, although none fully recapitulate the experimental evidence. In this review article, we will summarize the latest research on the epigenetic regulation of CTL differentiation as well as provide a combined model that contemplates them.PMID:34493604 | DOI:10.4049/jimmunol.2100633
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research